HCSGD entry for COL18A1
1. General information
| Official gene symbol | COL18A1 |
|---|---|
| Entrez ID | 80781 |
| Gene full name | collagen, type XVIII, alpha 1 |
| Other gene symbols | KNO KNO1 KS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001886 | Endothelial cell morphogenesis | IEA | biological_process |
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005581 | Collagen | IEA | cellular_component |
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007601 | Visual perception | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030335 | Positive regulation of cell migration | IEA | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA IEA TAS | cellular_component |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051599 | Response to hydrostatic pressure | IEA | biological_process |
| GO:2000353 | Positive regulation of endothelial cell apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8180710611 | 0.0062656016 | 0.9999902473 | 0.1614174168 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0193843982 |
| GSE13712_SHEAR | Down | -1.0790083932 |
| GSE13712_STATIC | Down | -0.3612171952 |
| GSE19018 | Up | 0.1098535535 |
| GSE19899_A1 | Down | -1.2640906596 |
| GSE19899_A2 | Down | -1.6634579804 |
| PubMed_21979375_A1 | Down | -1.9245635209 |
| PubMed_21979375_A2 | Down | -1.1069719281 |
| GSE35957 | Down | -0.5532213937 |
| GSE36640 | Down | -1.0214654534 |
| GSE54402 | Down | -0.6036340443 |
| GSE9593 | Up | 0.7853661176 |
| GSE43922 | Down | -0.0078141823 |
| GSE24585 | Down | -0.0232351414 |
| GSE37065 | Down | -0.1082962998 |
| GSE28863_A1 | Up | 0.2679378315 |
| GSE28863_A2 | Up | 0.3589360487 |
| GSE28863_A3 | Up | 0.1836185916 |
| GSE28863_A4 | Down | -0.1263368432 |
| GSE48662 | Down | -0.0953751678 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-3p | MIMAT0004950 | MIRT037044 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049203 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27165830 | Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney |
| 27165830 | Endostatin (EST), an antiangiogenic factor, is enriched in aging kidneys |
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