HCSGD entry for USP5
1. General information
| Official gene symbol | USP5 |
|---|---|
| Entrez ID | 8078 |
| Gene full name | ubiquitin specific peptidase 5 (isopeptidase T) |
| Other gene symbols | ISOT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004197 | Cysteine-type endopeptidase activity | TAS | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005764 | Lysosome | TAS | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0008242 | Omega peptidase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0032436 | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0071108 | Protein K48-linked deubiquitination | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3035539835 | 0.6634173436 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0007722437 |
| GSE13712_SHEAR | Up | 0.1025302601 |
| GSE13712_STATIC | Down | -0.0060863208 |
| GSE19018 | Up | 0.0255662971 |
| GSE19899_A1 | Down | -0.0261903104 |
| GSE19899_A2 | Up | 0.3194083363 |
| PubMed_21979375_A1 | Up | 0.2585075170 |
| PubMed_21979375_A2 | Up | 0.0142169466 |
| GSE35957 | Down | -0.1415073612 |
| GSE36640 | Up | 0.1338181400 |
| GSE54402 | Up | 0.1659608357 |
| GSE9593 | Up | 0.0164055438 |
| GSE43922 | Down | -0.0261753872 |
| GSE24585 | Down | -0.3744817293 |
| GSE37065 | Down | -0.0071968711 |
| GSE28863_A1 | Up | 0.2355903480 |
| GSE28863_A2 | Up | 0.1827030835 |
| GSE28863_A3 | Down | -0.2984418541 |
| GSE28863_A4 | Up | 0.0915570810 |
| GSE48662 | Up | 0.3161124972 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022686 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028484 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1180-3p | MIMAT0005825 | MIRT035949 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037909 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042352 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052708 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
