HCSGD entry for FGF23

1. General information

Official gene symbolFGF23
Entrez ID8074
Gene full namefibroblast growth factor 23
Other gene symbolsADHR FGFN HPDR2 HYPF PHPTC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005105Type 1 fibroblast growth factor receptor bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDA ISScellular_component
GO:0006796Phosphate-containing compound metabolic processIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010966Regulation of phosphate transportIDAbiological_process
GO:0010980Positive regulation of vitamin D 24-hydroxylase activityIDAbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030502Negative regulation of bone mineralizationIDAbiological_process
GO:0030643Cellular phosphate ion homeostasisIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042369Vitamin D catabolic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045668Negative regulation of osteoblast differentiationIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0046888Negative regulation of hormone secretionISSbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0055062Phosphate ion homeostasisIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0090080Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48276495950.89781927740.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0936940297
GSE13712_SHEARDown-0.1211238406
GSE13712_STATICUp0.1058802737
GSE19018Down-0.0948099305
GSE19899_A1Up0.1789720387
GSE19899_A2Up0.1278271703
PubMed_21979375_A1Down-0.1265565671
PubMed_21979375_A2Up0.0889644584
GSE35957Down-0.0101610490
GSE36640Up0.0069393066
GSE54402Up0.1604264755
GSE9593Down-0.0603296047
GSE43922Up0.0276723034
GSE24585Up0.1160271894
GSE37065Up0.0099583595
GSE28863_A1Down-0.1007629047
GSE28863_A2Up0.1032050231
GSE28863_A3Up0.3670084708
GSE28863_A4Down-0.0194158503
GSE48662Up0.0113504106

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017013MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT029016MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27125746Alpha-Klotho (alphaKlotho) protein is encoded by the gene, Klotho, and functions as a coreceptor for endocrine fibroblast growth factor-23
26797283Although muscle wasting and/or degeneration are prevalent in patients with chronic kidney disease, it remains unknown whether FGF-23 influences muscle homeostasis and regeneration
26797283In this study we sought to investigate the effects of FGF-23 on MSCs isolated from human skeletal muscle in vitro
26797283MSCs and satellite cells were treated with FGF-23 and angiotensin-II for 48 h
26797283Treatment with FGF-23 significantly decreased the number of MSCs compared to controls, while treatment with angiotensin-II did not
26797283FGF-23 and angiotensin-II both left the cell counts of the satellite cells unchanged
26797283FGF-23 also significantly altered the gene expression of oxidative stress regulators in the cells
26797283In conclusion, FGF-23 induced premature senescence in MSCs from skeletal muscle via the p53/p21/oxidative-stress pathway
26797283The interaction between the MSCs and FGF-23 may play a key role in the impaired muscle reparative mechanisms of chronic kidney disease
26528423Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of P i and vitamin D metabolism
25511229However, serum levels of oxidative stress and inflammatory markers, serum fibroblast growth factor 23, and aortic calcium content in CKD-CaC rats were higher than those in CKD-LaC rats
23666415FGF23 and Klotho in chronic kidney disease
23666415PURPOSE OF REVIEW: The wealth of data regarding fibroblast growth factor-23 (FGF23) and Klotho in chronic kidney disease (CKD) has risen exponentially over the past decade
23666415RECENT FINDINGS: The phosphaturic hormone FGF23 increases dramatically as renal function declines
23666415Identification of contributing stimuli to the rise in FGF23 is fundamental and recent evidence suggest a multifactorial cause which entails perturbed osteocyte function and renal mechanisms such as Klotho deficiency and, somewhat paradoxically, systemic Klotho excess
23666415Circulating FGF23 predicts adverse outcomes, particularly cardiovascular disease, in CKD as well as in the general population
23666415The concept of FGF23 merely as a biomarker and regulator of mineral metabolism is currently challenged by data linking FGF23 to pathological processes such as cardiac hypertrophy
23666415Conversely, tissue level of the FGF23 coreceptor Klotho declines in early CKD and this deficiency is linked to accelerated ageing, cellular senescence, vascular calcification, oxidative stress and renal fibrosis
222421931,25-dihydroxyvitamin D3 (1,25D3) was reported to induce premature organismal aging in fibroblast growth factor-23 (Fgf23) and klotho deficient mice, which is of main interest as 1,25D3 supplementation of its precursor cholecalciferol is used in basic osteoporosis treatment
21235497This review discusses the molecular mechanisms of cellular senescence and its affect on calcification of vascular cells, the relevance of phosphate regulation and the function of FGF23 and Klotho proteins
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