HCSGD entry for CUL5
1. General information
| Official gene symbol | CUL5 |
|---|---|
| Entrez ID | 8065 |
| Gene full name | cullin 5 |
| Other gene symbols | VACM-1 VACM1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005262 | Calcium channel activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006812 | Cation transport | TAS | biological_process |
| GO:0006970 | Response to osmotic stress | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0030001 | Metal ion transport | TAS | biological_process |
| GO:0031461 | Cullin-RING ubiquitin ligase complex | IEA | cellular_component |
| GO:0031466 | Cul5-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IDA IEA | molecular_function |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0051480 | Cytosolic calcium ion homeostasis | IEA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0070588 | Calcium ion transmembrane transport | TAS | biological_process |
| GO:0072511 | Divalent inorganic cation transport | TAS | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4629603738 | 0.5110511037 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0082058995 |
| GSE13712_SHEAR | Down | -0.0730984678 |
| GSE13712_STATIC | Down | -0.0151993873 |
| GSE19018 | Down | -0.0165386172 |
| GSE19899_A1 | Up | 0.0152176162 |
| GSE19899_A2 | Up | 0.5800249322 |
| PubMed_21979375_A1 | Up | 0.3006909942 |
| PubMed_21979375_A2 | Up | 0.2339656100 |
| GSE35957 | Down | -0.0956970985 |
| GSE36640 | Up | 0.0155419899 |
| GSE54402 | Up | 0.0803271994 |
| GSE9593 | Down | -0.0513668915 |
| GSE43922 | Up | 0.0171182740 |
| GSE24585 | Up | 0.0582211470 |
| GSE37065 | Up | 0.1397002485 |
| GSE28863_A1 | Down | -0.3175712704 |
| GSE28863_A2 | Down | -0.0330160737 |
| GSE28863_A3 | Down | -0.8986036908 |
| GSE28863_A4 | Up | 0.2505098034 |
| GSE48662 | Up | 0.1188936740 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004846 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blot;Microarray;Other | Functional MTI | 19074876 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT006475 | qRT-PCR//Western blot | Functional MTI | 22561557 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT006476 | qRT-PCR//Western blot | Functional MTI | 22561557 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019403 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-375 | MIMAT0000728 | MIRT019963 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024359 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-484 | MIMAT0002174 | MIRT042216 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048574 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049218 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
