HCSGD entry for ADAM12
1. General information
| Official gene symbol | ADAM12 |
|---|---|
| Entrez ID | 8038 |
| Gene full name | ADAM metallopeptidase domain 12 |
| Other gene symbols | MCMP MCMPMltna MLTN MLTNA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007520 | Myoblast fusion | TAS | biological_process |
| GO:0008237 | Metallopeptidase activity | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0017124 | SH3 domain binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1624052620 | 0.0503312032 | 0.7974773304 | 0.4201841104 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0809692230 |
| GSE13712_SHEAR | Down | -0.0423780481 |
| GSE13712_STATIC | Down | -0.3538543117 |
| GSE19018 | Down | -0.7703121531 |
| GSE19899_A1 | Up | 0.2722882442 |
| GSE19899_A2 | Down | -0.1899724809 |
| PubMed_21979375_A1 | Up | 0.6904247766 |
| PubMed_21979375_A2 | Up | 0.1978933790 |
| GSE35957 | Down | -0.1732775630 |
| GSE36640 | Up | 0.2742319809 |
| GSE54402 | Up | 0.0852414737 |
| GSE9593 | Down | -0.2792089622 |
| GSE43922 | Up | 1.0832992011 |
| GSE24585 | Down | -1.0338323452 |
| GSE37065 | Down | -0.2931368873 |
| GSE28863_A1 | Up | 0.3384845747 |
| GSE28863_A2 | Up | 0.4369854853 |
| GSE28863_A3 | Up | 0.2031224809 |
| GSE28863_A4 | Down | -0.1145104351 |
| GSE48662 | Down | -0.2329282765 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29b-3p | MIMAT0000100 | MIRT005667 | Luciferase reporter assay//Microarray//Northern blot//qRT-PCR | Functional MTI | 20971881 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT005667 | Luciferase reporter assay//Microarray//qRT-PCR | Functional MTI | 19956414 |
| hsa-miR-1 | MIMAT0000416 | MIRT023733 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
