HCSGD entry for PNPLA3

1. General information

Official gene symbolPNPLA3
Entrez ID80339
Gene full namepatatin-like phospholipase domain containing 3
Other gene symbolsADPN C22orf20 iPLA(2)epsilon
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004623Phospholipase A2 activityIDAmolecular_function
GO:0004806Triglyceride lipase activityIDAmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0008152Metabolic processIEAbiological_process
GO:0016020MembraneISScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019432Triglyceride biosynthetic processIDAbiological_process
GO:0019433Triglyceride catabolic processIDA IEAbiological_process
GO:0036155Acylglycerol acyl-chain remodelingTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046474Glycerophospholipid biosynthetic processTASbiological_process
GO:0051264Mono-olein transacylation activityIDAmolecular_function
GO:0051265Diolein transacylation activityIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00504045440.59004716010.18607265081.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3459064860
GSE13712_SHEARDown-0.4520420280
GSE13712_STATICDown-0.1805691285
GSE19018Up0.1372660181
GSE19899_A1Up0.6671791101
GSE19899_A2Up2.5788336300
PubMed_21979375_A1Up0.2504737556
PubMed_21979375_A2Up2.3200141704
GSE35957Down-0.3224440131
GSE36640Up1.1122023275
GSE54402Up0.7151222636
GSE9593Up1.0739446366
GSE43922Up0.9407083205
GSE24585Down-0.1167978094
GSE37065Up0.1014074882
GSE28863_A1Down-0.6173689581
GSE28863_A2Down-0.2269926479
GSE28863_A3Up0.3206915338
GSE28863_A4Down-0.1872434628
GSE48662Down-0.1499552494

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016844MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.