HCSGD entry for ULBP2
1. General information
| Official gene symbol | ULBP2 |
|---|---|
| Entrez ID | 80328 |
| Gene full name | UL16 binding protein 2 |
| Other gene symbols | N2DL2 RAET1H |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003823 | Antigen binding | IBA | molecular_function |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0019882 | Antigen processing and presentation | IBA | biological_process |
| GO:0030101 | Natural killer cell activation | IDA | biological_process |
| GO:0042267 | Natural killer cell mediated cytotoxicity | IDA | biological_process |
| GO:0046658 | Anchored component of plasma membrane | IDA | cellular_component |
| GO:0046703 | Natural killer cell lectin-like receptor binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0043574294 | 0.7116153414 | 0.1760215926 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3080271486 |
| GSE13712_SHEAR | Down | -0.5959432470 |
| GSE13712_STATIC | Down | -0.5721332244 |
| GSE19018 | Up | 0.8079123887 |
| GSE19899_A1 | Up | 0.6764219612 |
| GSE19899_A2 | Up | 1.2876006357 |
| PubMed_21979375_A1 | Up | 1.0238516968 |
| PubMed_21979375_A2 | Up | 0.5817262247 |
| GSE35957 | Down | -0.2314412259 |
| GSE36640 | Up | 2.6340209038 |
| GSE54402 | Up | 0.6134611361 |
| GSE9593 | Down | -0.2073307724 |
| GSE43922 | Up | 0.5684410341 |
| GSE24585 | Up | 0.3311729854 |
| GSE37065 | Up | 0.0703187556 |
| GSE28863_A1 | Down | -0.2044790678 |
| GSE28863_A2 | Down | -0.2462384163 |
| GSE28863_A3 | Up | 0.1705932640 |
| GSE28863_A4 | Down | -0.1852002680 |
| GSE48662 | Down | -0.2175229073 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT006286 | Flow//Luciferase reporter assay//Western blot | Functional MTI | 22102694 |
| hsa-miR-34c-5p | MIMAT0000686 | MIRT006287 | Flow//Luciferase reporter assay//Western blot | Functional MTI | 22102694 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26878797 | Here we show that ligands of an activating Natural Killer (NK) cell receptor (NKG2D), MICA and ULBP2 are consistently up-regulated following induction of replicative senescence, oncogene-induced senescence and DNA damage - induced senescence |
| 26878797 | MICA and ULBP2 proteins are necessary for efficient NK-mediated cytotoxicity towards senescent fibroblasts |
| 26046815 | Our studies demonstrate that endogenous IFN produced by already senescent cells contribute to increased expression of the natural killer (NK) receptor ligands, including MIC-A and ULBP2 |
| 21764762 | Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2 |
| 21764762 | Accordingly, treatment of certain wild-type p53-expressing tumor cell lines with the p53-reactivating small molecular compound RITA resulted in upregulation of ULBP2 mRNA and cell surface protein expression |
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