HCSGD entry for PUS1
1. General information
| Official gene symbol | PUS1 |
|---|---|
| Entrez ID | 80324 |
| Gene full name | pseudouridylate synthase 1 |
| Other gene symbols | MLASA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001522 | Pseudouridine synthesis | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004730 | Pseudouridylate synthase activity | NAS | molecular_function |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0008033 | TRNA processing | IEA | biological_process |
| GO:0009982 | Pseudouridine synthase activity | IEA | molecular_function |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | IEA | molecular_function |
| GO:0031119 | TRNA pseudouridine synthesis | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0572385320 | 0.3423097337 | 0.5199236715 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2668140120 |
| GSE13712_SHEAR | Up | 0.6011199575 |
| GSE13712_STATIC | Up | 0.2673614618 |
| GSE19018 | Down | -0.4830593123 |
| GSE19899_A1 | Up | 0.0703305355 |
| GSE19899_A2 | Up | 1.0886050091 |
| PubMed_21979375_A1 | Up | 1.0250229939 |
| PubMed_21979375_A2 | Up | 0.5152425000 |
| GSE35957 | Down | -0.5140071253 |
| GSE36640 | Down | -0.3298901261 |
| GSE54402 | Up | 0.3656448649 |
| GSE9593 | Down | -0.2682844549 |
| GSE43922 | Up | 0.4986057347 |
| GSE24585 | Down | -0.9907557866 |
| GSE37065 | Down | -0.1047702699 |
| GSE28863_A1 | Down | -0.1973851960 |
| GSE28863_A2 | Down | -0.1303787794 |
| GSE28863_A3 | Up | 0.3013237135 |
| GSE28863_A4 | Up | 0.0640382259 |
| GSE48662 | Up | 0.0832554956 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022192 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027453 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032213 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041439 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
