HCSGD entry for TET1
1. General information
| Official gene symbol | TET1 |
|---|---|
| Entrez ID | 80312 |
| Gene full name | tet methylcytosine dioxygenase 1 |
| Other gene symbols | CXXC6 LCX bA119F7.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001826 | Inner cell mass cell differentiation | ISS | biological_process |
| GO:0005506 | Iron ion binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IC | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006493 | Protein O-linked glycosylation | ISS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0019827 | Stem cell maintenance | ISS | biological_process |
| GO:0043566 | Structure-specific DNA binding | IDA | molecular_function |
| GO:0044030 | Regulation of DNA methylation | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0070579 | Methylcytosine dioxygenase activity | IDA IMP | molecular_function |
| GO:0080111 | DNA demethylation | IMP | biological_process |
| GO:0090310 | Negative regulation of methylation-dependent chromatin silencing | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9804571673 | 0.0011655788 | 0.9999902473 | 0.0647926316 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2458160266 |
| GSE13712_SHEAR | Down | -0.3845728681 |
| GSE13712_STATIC | Down | -0.2187918051 |
| GSE19018 | Down | -0.0546328244 |
| GSE19899_A1 | Down | -0.0478832711 |
| GSE19899_A2 | Down | -3.1359704910 |
| PubMed_21979375_A1 | Down | -2.1752205480 |
| PubMed_21979375_A2 | Down | -1.4967545782 |
| GSE35957 | Down | -0.4418033228 |
| GSE36640 | Down | -2.0533570409 |
| GSE54402 | Down | -0.8441527466 |
| GSE9593 | Down | -0.9225540427 |
| GSE43922 | Down | -2.0283043056 |
| GSE24585 | Up | 0.0932770988 |
| GSE37065 | Down | -0.1046230998 |
| GSE28863_A1 | Up | 0.5233518991 |
| GSE28863_A2 | Up | 0.4589800477 |
| GSE28863_A3 | Down | -0.3068134956 |
| GSE28863_A4 | Down | -0.3107817862 |
| GSE48662 | Down | -0.1038138718 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29b-3p | MIMAT0000100 | MIRT004419 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19850741 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT004420 | qRT-PCR | Functional MTI (Weak) | 19850741 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030814 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037234 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-454-3p | MIMAT0003885 | MIRT039236 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29a-3p | MIMAT0000086 | NA | hsa-miR-29a | {Western blot} | {overexpression} | 19850741 | |
| hsa-miR-29b-3p | MIMAT0000100 | 2 | hsa-miR-29b | {Western blot} | {overexpression} | 19850741 | |
| hsa-miR-29b-3p | MIMAT0000100 | 3 | hsa-miR-29b | {Western blot} | {overexpression} | 19850741 | |
| hsa-miR-29b-3p | MIMAT0000100 | 1 | hsa-miR-29b | {Western blot} | {overexpression} | 19850741 | |
| hsa-miR-29b-3p | MIMAT0000100 | 4 | hsa-miR-29b | {Western blot} | {overexpression} | 19850741 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24804545 | Notably, PRIMA-1 dramatically increased the expression of the ten-eleven translocation (TET) family of 5mC-hydroxylases, particularly TET1, in p53 mutant-type cells, further contributing to DNA demethylation |
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