HCSGD entry for RNF34
1. General information
| Official gene symbol | RNF34 |
|---|---|
| Entrez ID | 80196 |
| Gene full name | ring finger protein 34, E3 ubiquitin protein ligase |
| Other gene symbols | CARP-1 CARP1 RFI RIF RIFF hRFI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:1901981 | Phosphatidylinositol phosphate binding | IDA | molecular_function |
| GO:1902042 | Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | IMP | biological_process |
| GO:2001271 | Negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8578805251 | 0.1940594734 | 0.9999902473 | 0.8535715288 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2387914401 |
| GSE13712_SHEAR | Up | 0.0557821709 |
| GSE13712_STATIC | Up | 0.0181014952 |
| GSE19018 | Down | -0.0547675330 |
| GSE19899_A1 | Down | -0.1570831477 |
| GSE19899_A2 | Down | -0.2794459054 |
| PubMed_21979375_A1 | Down | -0.2676674089 |
| PubMed_21979375_A2 | Down | -0.3126836525 |
| GSE35957 | Down | -0.2382592136 |
| GSE36640 | Down | -0.9844387994 |
| GSE54402 | Up | 0.3350630746 |
| GSE9593 | Down | -0.2381718084 |
| GSE43922 | Down | -0.0116784651 |
| GSE24585 | Up | 0.1312875341 |
| GSE37065 | Up | 0.0336277067 |
| GSE28863_A1 | Up | 0.0711736332 |
| GSE28863_A2 | Up | 0.1278550453 |
| GSE28863_A3 | Down | -0.1591749064 |
| GSE28863_A4 | Up | 0.0676137948 |
| GSE48662 | Down | -0.4501226081 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025100 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028023 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT046149 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047982 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
