HCSGD entry for CEP290

1. General information

Official gene symbolCEP290
Entrez ID80184
Gene full namecentrosomal protein 290kDa
Other gene symbols3H11Ag BBS14 CT87 JBTS5 LCA10 MKS4 NPHP6 POC3 SLSN6 rd16
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000930Gamma-tubulin complexIDAcellular_component
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDA IEAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0007163Establishment or maintenance of cell polarityIEAbiological_process
GO:0015031Protein transportISSbiological_process
GO:0030814Regulation of cAMP metabolic processIEAbiological_process
GO:0030902Hindbrain developmentISSbiological_process
GO:0030916Otic vesicle formationISSbiological_process
GO:0032391Photoreceptor connecting ciliumISScellular_component
GO:0036038TCTN-B9D complexISScellular_component
GO:0042384Cilium assemblyISSbiological_process
GO:0042462Eye photoreceptor cell developmentISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0048793Pronephros developmentISSbiological_process
GO:0051011Microtubule minus-end bindingIDAmolecular_function
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:0060271Cilium morphogenesisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83628969640.11640063450.99999024730.6537990194

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1061096258
GSE13712_SHEARUp0.0874113705
GSE13712_STATICUp0.2401886610
GSE19018Up0.1042388484
GSE19899_A1Down-0.1351840063
GSE19899_A2Down-0.7002341627
PubMed_21979375_A1Down-0.2838252332
PubMed_21979375_A2Down-0.6665974531
GSE35957Down-0.4158727994
GSE36640Down-0.0880691282
GSE54402Down-0.2188511029
GSE9593Down-0.0876931359
GSE43922Down-0.5265331028
GSE24585Down-0.2725046297
GSE37065Down-0.0481042491
GSE28863_A1Up0.4917044592
GSE28863_A2Up0.2397144975
GSE28863_A3Down-0.1344126049
GSE28863_A4Up0.1879518571
GSE48662Down-0.2253882103

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.