HCSGD entry for PANK2


1. General information

Official gene symbolPANK2
Entrez ID80025
Gene full namepantothenate kinase 2
Other gene symbolsC20orf48 HARP HSS NBIA1 PKAN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004594Pantothenate kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005758Mitochondrial intermembrane spaceTAScellular_component
GO:0005829CytosolIEAcellular_component
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0007286Spermatid developmentIEAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0009060Aerobic respirationIEAbiological_process
GO:0009108Coenzyme biosynthetic processTASbiological_process
GO:0015937Coenzyme A biosynthetic processIEAbiological_process
GO:0015939Pantothenate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051881Regulation of mitochondrial membrane potentialIEAbiological_process
GO:0070584Mitochondrion morphogenesisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55374249460.14544412070.99999024730.7356331091

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0977263162
GSE13712_SHEARDown-0.0103660756
GSE13712_STATICUp0.1549027811
GSE19018Down-0.5083181911
GSE19899_A1Up0.1135079612
GSE19899_A2Up0.0073493260
PubMed_21979375_A1Up0.5681602778
PubMed_21979375_A2Down-0.6223148243
GSE35957Down-0.1080064374
GSE36640Down-0.2899898023
GSE54402Up0.1824350981
GSE9593Down-0.2056869924
GSE43922Up0.1448262055
GSE24585Up0.3324081832
GSE37065Down-0.1242646823
GSE28863_A1Down-0.0554895591
GSE28863_A2Down-0.5345335665
GSE28863_A3Down-0.5812844832
GSE28863_A4Up0.1481198171
GSE48662Down-0.1773966845

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-877-3pMIMAT0004950MIRT036836CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039651CLASHFunctional MTI (Weak)23622248
hsa-miR-497-5pMIMAT0002820MIRT041189CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046370CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047610CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049757CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.