HCSGD entry for UBTD1

1. General information

Official gene symbolUBTD1
Entrez ID80019
Gene full nameubiquitin domain containing 1
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

Not in the Gene ontology

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02700653090.93926303710.38205045671.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2337330826
GSE13712_SHEARDown-0.8362960406
GSE13712_STATICDown-0.3045586004
GSE19018Up0.1981079405
GSE19899_A1Up0.3247053616
GSE19899_A2Up0.6366878729
PubMed_21979375_A1Up0.5226689812
PubMed_21979375_A2Up1.8678981152
GSE35957Up0.2481972694
GSE36640Up0.2743033475
GSE54402Up0.2167349885
GSE9593Up0.3498020019
GSE43922Up0.2066910664
GSE24585Up0.0064989696
GSE37065Down-0.1225930808
GSE28863_A1Down-0.0002808699
GSE28863_A2Up0.0893504588
GSE28863_A3Up0.0711615710
GSE28863_A4Up0.0309161513
GSE48662Up0.3145507376

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25382750Here, we report that the ubiquitin domain-containing 1 (UBTD1) gene, a new downstream target of p53, induces cellular senescence and acts as a novel tumour suppressor by a mechanism that depends on p53
25382750Expression of UBTD1 increased upon cellular senescence induced by serial passageing of cultures, as well as by exposure to DNA-damageing drugs that induce premature senescence
25382750Over-expression of UBTD1 induces senescence in human fibroblasts and cancer cells and attenuation of the transformed phenotype in cancer cells
25382750UBTD1 is down-regulated in gastric and colorectal cancer tissues, and its lower expression correlates with a more aggressive phenotype and worse prognosis
25382750Multivariate analysis revealed that UBTD1 expression was an independent prognostic factor for gastric cancer patients
25382750Furthermore, UBTD1 increased the stability of p53 protein, by promoting the degradation of Mdm2 protein
25382750Importantly, UBTD1 and p53 function mutually depend on each other in regulating cellular senescence and proliferation
25382750Thus, our data suggest that, upon DNA damage, p53 induction by UBTD1 creates a positive feedback mechanism to further increase p53 expression
25382750Our results establish UBTD1 as a regulator of cellular senescence that mediates p53 function, and provide insights into the mechanism of Mdm2 inhibition that impacts p53 dynamics during cellular senescence and tumourigenesis
Entries Per Page
Displaying Page of