HCSGD entry for CALCR

1. General information

Official gene symbolCALCR
Entrez ID799
Gene full namecalcitonin receptor
Other gene symbolsCRT CT-R CTR CTR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004872Receptor activityIDAmolecular_function
GO:0004948Calcitonin receptor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0007165Signal transductionIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIDA NASbiological_process
GO:0007190Activation of adenylate cyclase activityIDAbiological_process
GO:0007202Activation of phospholipase C activityIDAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDAbiological_process
GO:0008565Protein transporter activityIDAmolecular_function
GO:0015031Protein transportIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030819Positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0031623Receptor internalizationIDAbiological_process
GO:0032841Calcitonin bindingIDA IPImolecular_function
GO:0045762Positive regulation of adenylate cyclase activityIDAbiological_process
GO:0051384Response to glucocorticoidIDAbiological_process
GO:0072659Protein localization to plasma membraneIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51920031530.90574543900.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1277144616
GSE13712_SHEARUp0.1556140295
GSE13712_STATICUp0.0600237543
GSE19018Up0.1621053813
GSE19899_A1Up0.1266449760
GSE19899_A2Up0.1024561333
PubMed_21979375_A1Down-0.0542440071
PubMed_21979375_A2Up0.0104010414
GSE35957Up0.1004278954
GSE36640Down-0.0128140078
GSE54402Up0.0326243799
GSE9593Down-0.0482900674
GSE43922Down-0.0491730760
GSE24585Up0.5626201524
GSE37065Down-0.0317898707
GSE28863_A1Up0.0112426281
GSE28863_A2Up0.0088188495
GSE28863_A3Up0.1315968743
GSE28863_A4Up0.0122375145
GSE48662Up0.0097610292

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PramlintideDB01278 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23830072Epidemiological data exist to support a positive association between Chlamydia trachomatis (Ctr) infection and gynecological cancers; however, putative cellular mechanisms for this association are lacking
23830072In cells cleared of Ctr infection, average telomere length was slightly increased and immunofluorescence staining of the DNA damage marker gammaH2A
23830072Thus, Ctr infection altered cell aging and survival pathways, which persisted after infection clearance
22692818Therefore, we also included miR-146a expression determination in CACs from 37 CHF patients and 35 healthy control subjects (CTR) for this study
22692818Interestingly, a 1,000-fold increased expression of miR-146a was observed in CACs of CHF patients compared to CTR, along with decreased expression of IRAK1 protein
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