HCSGD entry for NHEJ1
1. General information
| Official gene symbol | NHEJ1 |
|---|---|
| Entrez ID | 79840 |
| Gene full name | nonhomologous end-joining factor 1 |
| Other gene symbols | XLF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0006302 | Double-strand break repair | IEA | biological_process |
| GO:0006303 | Double-strand break repair via nonhomologous end joining | IMP | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0007417 | Central nervous system development | NAS | biological_process |
| GO:0010212 | Response to ionizing radiation | IDA | biological_process |
| GO:0030183 | B cell differentiation | IMP | biological_process |
| GO:0030217 | T cell differentiation | IMP | biological_process |
| GO:0051351 | Positive regulation of ligase activity | NAS | biological_process |
| GO:0070419 | Nonhomologous end joining complex | IDA | cellular_component |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9701025645 | 0.5109318681 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.1727863389 |
| GSE28863_A2 | Up | 0.0936297622 |
| GSE28863_A3 | Down | -0.0605305232 |
| GSE28863_A4 | Down | -0.1317987016 |
| GSE48662 | Down | -0.2608853136 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24626809 | Werner syndrome protein positively regulates XRCC4-like factor transcription |
| 24626809 | XRCC4-like factor (XLF) is involved in non-homologous end joining-mediated repair of DNA double-strand breaks (DSBs) |
| 24626809 | In the present study, it was identified that XLF protein levels were lower in WRN-deficient fibroblasts, compared with normal fibroblasts |
| 24626809 | Depletion of WRN in HeLa cells led to a decrease of XLF mRNA and its promoter activity |
| 24626809 | Chromatin immunoprecipitation assays demonstrated that WRN was associated with the XLF promoter |
| 24626809 | Depletion of XLF in normal human fibroblasts increased the percentage of beta-galactosidase (beta-gal) staining-positive cells, indicating acceleration in cellular senescence |
| 24626809 | Taken together, the results suggest that XLF is a transcriptional target of WRN and may be involved in the regulation of cellular senescence |
Entries Per Page
Displaying Page of
