HCSGD entry for ARHGEF5
1. General information
| Official gene symbol | ARHGEF5 |
|---|---|
| Entrez ID | 7984 |
| Gene full name | Rho guanine nucleotide exchange factor (GEF) 5 |
| Other gene symbols | GEF5 P60 TIM TIM1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002408 | Myeloid dendritic cell chemotaxis | IEA | biological_process |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | TAS | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0030036 | Actin cytoskeleton organization | IEA | biological_process |
| GO:0032319 | Regulation of Rho GTPase activity | IDA | biological_process |
| GO:0032321 | Positive regulation of Rho GTPase activity | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0071803 | Positive regulation of podosome assembly | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8940955283 | 0.1738080544 | 0.9999902473 | 0.8073529723 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0969314426 |
| GSE13712_SHEAR | Down | -0.3354650416 |
| GSE13712_STATIC | Up | 0.1534396155 |
| GSE19018 | Down | -0.0514606830 |
| GSE19899_A1 | Up | 0.0998813345 |
| GSE19899_A2 | Up | 0.0110531084 |
| PubMed_21979375_A1 | Down | -0.0935002520 |
| PubMed_21979375_A2 | Down | -0.1847469010 |
| GSE35957 | Up | 0.4084843789 |
| GSE36640 | Down | -1.8460010147 |
| GSE54402 | Down | -0.4769323474 |
| GSE9593 | Up | 0.4019471849 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.0133953158 |
| GSE28863_A2 | Up | 0.0388020737 |
| GSE28863_A3 | Down | -0.0273627735 |
| GSE28863_A4 | Down | -0.1088369046 |
| GSE48662 | Down | -0.0736856081 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030322 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047144 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052259 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
