HCSGD entry for EHMT1
1. General information
| Official gene symbol | EHMT1 |
|---|---|
| Entrez ID | 79813 |
| Gene full name | euchromatic histone-lysine N-methyltransferase 1 |
| Other gene symbols | EUHMTASE1 Eu-HMTase1 FP13812 GLP GLP1 KMT1D bA188C12.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0002039 | P53 binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IC ISS | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0006306 | DNA methylation | ISS | biological_process |
| GO:0008168 | Methyltransferase activity | IDA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009790 | Embryo development | ISS | biological_process |
| GO:0016279 | Protein-lysine N-methyltransferase activity | IDA | molecular_function |
| GO:0016568 | Chromatin modification | IDA | biological_process |
| GO:0016571 | Histone methylation | IDA | biological_process |
| GO:0018024 | Histone-lysine N-methyltransferase activity | IDA | molecular_function |
| GO:0018026 | Peptidyl-lysine monomethylation | ISS | biological_process |
| GO:0018027 | Peptidyl-lysine dimethylation | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0046974 | Histone methyltransferase activity (H3-K9 specific) | ISS | molecular_function |
| GO:0046976 | Histone methyltransferase activity (H3-K27 specific) | ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0770013107 | 0.9329653927 | 0.5860992486 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0026044109 |
| GSE13712_SHEAR | Up | 0.5308081299 |
| GSE13712_STATIC | Up | 0.3091264429 |
| GSE19018 | Down | -0.0530882498 |
| GSE19899_A1 | Down | -0.0578520398 |
| GSE19899_A2 | Up | 0.5147464695 |
| PubMed_21979375_A1 | Up | 0.3108627169 |
| PubMed_21979375_A2 | Up | 0.5256428935 |
| GSE35957 | Down | -0.0522021294 |
| GSE36640 | Down | -0.2562950393 |
| GSE54402 | Up | 0.1301459913 |
| GSE9593 | Down | -0.2601521627 |
| GSE43922 | Up | 0.0622218979 |
| GSE24585 | Up | 0.8547423105 |
| GSE37065 | Down | -0.0955700688 |
| GSE28863_A1 | Up | 0.3012395563 |
| GSE28863_A2 | Up | 0.2580861697 |
| GSE28863_A3 | Up | 0.1146493950 |
| GSE28863_A4 | Down | -0.0173792558 |
| GSE48662 | Up | 0.0677049417 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001369 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040045 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042121 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30e-5p | MIMAT0000692 | MIRT044136 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046028 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19944017 | We found that the chromatin modifier-encoding genes Eu-HMTase1, ZMYND11, and RASA3 were overexpressed in adults |
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