HCSGD entry for FBXO31
1. General information
| Official gene symbol | FBXO31 |
|---|---|
| Entrez ID | 79791 |
| Gene full name | F-box protein 31 |
| Other gene symbols | FBX14 FBXO14 Fbx31 pp2386 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0008054 | Cyclin catabolic process | IMP | biological_process |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0019005 | SCF ubiquitin ligase complex | IDA IEA | cellular_component |
| GO:0030332 | Cyclin binding | IEA IPI | molecular_function |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA IEA | biological_process |
| GO:0031571 | Mitotic G1 DNA damage checkpoint | IEA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0177057825 | 0.9945708142 | 0.3263542717 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2033668030 |
| GSE13712_SHEAR | Up | 0.1411841356 |
| GSE13712_STATIC | Up | 0.3725417477 |
| GSE19018 | Down | -0.1085287887 |
| GSE19899_A1 | Up | 0.0512139791 |
| GSE19899_A2 | Up | 0.5080128668 |
| PubMed_21979375_A1 | Up | 0.8364254455 |
| PubMed_21979375_A2 | Up | 1.0847120122 |
| GSE35957 | Up | 0.2148436130 |
| GSE36640 | Up | 0.7377393349 |
| GSE54402 | Up | 0.0771659054 |
| GSE9593 | Up | 0.2410305215 |
| GSE43922 | Up | 0.0393517060 |
| GSE24585 | Up | 0.3009942630 |
| GSE37065 | Down | -0.0935280065 |
| GSE28863_A1 | Up | 0.5354191950 |
| GSE28863_A2 | Up | 0.6625819107 |
| GSE28863_A3 | Up | 0.1538851579 |
| GSE28863_A4 | Up | 0.0554337539 |
| GSE48662 | Up | 0.1073865015 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-17-5p | MIMAT0000070 | MIRT004529 | Luciferase reporter assay | Functional MTI | 19734348 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026239 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040530 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040924 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044521 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22363855 | Redundant, secondary senescence systems are also present and include the p14-p53-p21 pathway, the IGFBP7 pathway, the FBXO31 pathway, and the PI3K mediated stress induced endoplasmic reticulum unfolded protein response |
| 16357137 | FBXO31 is the chromosome 16q24 |
| 16357137 | We have shown that FBXO31, although located just distal to this BAC, can induce cellular senescence in the breast cancer cell line MCF-7 and is the likely candidate senescence gene |
| 16357137 | FBXO31 has properties consistent with a tumor suppressor, because ectopic expression of FBXO31 in two breast cancer cell lines inhibited colony growth on plastic and inhibited cell proliferation in the MCF-7 cell line |
| 16357137 | In addition, compared with the relative expression in normal breast, levels of FBXO31 were down-regulated in breast tumor cell lines and primary tumors |
| 16357137 | Ectopic expression of FBXO31 in the breast cancer cell line MDA-MB-468 resulted in the accumulation of cells at the G(1) phase of the cell cycle |
| 16357137 | We propose that FBXO31 functions as a tumor suppressor by generating SCF(FBXO31) complexes that target particular substrates, critical for the normal execution of the cell cycle, for ubiquitination and subsequent degradation |
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