HCSGD entry for TXNDC15
1. General information
| Official gene symbol | TXNDC15 |
|---|---|
| Entrez ID | 79770 |
| Gene full name | thioredoxin domain containing 15 |
| Other gene symbols | C5orf14 UNQ335 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5345163178 | 0.1491487481 | 0.9999902473 | 0.7467651132 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1771948488 |
| GSE13712_SHEAR | Up | 0.0076422782 |
| GSE13712_STATIC | Down | -0.1865651244 |
| GSE19018 | Up | 0.0595236950 |
| GSE19899_A1 | Down | -0.7784702796 |
| GSE19899_A2 | Down | -0.1504802101 |
| PubMed_21979375_A1 | Down | -0.5621017988 |
| PubMed_21979375_A2 | Down | -0.6909941695 |
| GSE35957 | Down | -0.0943816169 |
| GSE36640 | Up | 0.7608230330 |
| GSE54402 | Down | -0.3980956785 |
| GSE9593 | Up | 0.4481111313 |
| GSE43922 | Down | -0.0690732588 |
| GSE24585 | Up | 0.2125362205 |
| GSE37065 | Up | 0.2158663053 |
| GSE28863_A1 | Up | 0.1798197370 |
| GSE28863_A2 | Up | 0.1624414089 |
| GSE28863_A3 | Down | -0.3689887161 |
| GSE28863_A4 | Down | -0.3145590056 |
| GSE48662 | Up | 0.4039310543 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050736 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25526565 | TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology |
| 25149687 | Results show that in replicative senescence and CuSO4-SIPS, immunoglobulin binding protein, calnexin, protein disulfide isomerase, and ER oxireductin-1 levels adjust to restore proteostasis and inositol-requiring enzyme-1 (IRE1)-, activating transcription factor 6 (ATF6)-, and pancreatic ER kinase (PERK)-mediated unfolded protein response are activated |
| 22668500 | Proteomic analysis demonstrated the involvement of proteins from other pathways besides those related to the cell cycle, including protein disulfide isomerase A3, heat-shock protein 70, and fructose biphosphate aldolase A (all up-regulated), and lactate dehydrogenase (down-regulated) |
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