HCSGD entry for TBL1XR1
1. General information
| Official gene symbol | TBL1XR1 |
|---|---|
| Entrez ID | 79718 |
| Gene full name | transducin (beta)-like 1 X-linked receptor 1 |
| Other gene symbols | C21 DC42 IRA1 TBLR1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000118 | Histone deacetylase complex | IDA | cellular_component |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0003714 | Transcription corepressor activity | IDA IEA IGI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005876 | Spindle microtubule | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0008013 | Beta-catenin binding | IPI | molecular_function |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0017053 | Transcriptional repressor complex | IDA | cellular_component |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IEA ISS | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA IEA ISS | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
| GO:0060070 | Canonical Wnt signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9915414308 | 0.0039900270 | 0.9999902473 | 0.1281476829 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4560064728 |
| GSE13712_SHEAR | Up | 0.0150518913 |
| GSE13712_STATIC | Up | 0.0783169474 |
| GSE19018 | Up | 0.0532847822 |
| GSE19899_A1 | Down | -0.2850603706 |
| GSE19899_A2 | Down | -0.6778581731 |
| PubMed_21979375_A1 | Down | -0.7420103873 |
| PubMed_21979375_A2 | Down | -0.4315905820 |
| GSE35957 | Up | 0.2571891515 |
| GSE36640 | Down | -0.4995973326 |
| GSE54402 | Down | -0.2312827012 |
| GSE9593 | Down | -0.2474759925 |
| GSE43922 | Down | -0.3361085855 |
| GSE24585 | Down | -0.4238918415 |
| GSE37065 | Down | -0.1289660283 |
| GSE28863_A1 | Down | -0.6145723561 |
| GSE28863_A2 | Down | -0.3805468276 |
| GSE28863_A3 | Down | -0.6681016946 |
| GSE28863_A4 | Down | -0.5057527858 |
| GSE48662 | Up | 0.3712141360 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019306 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023246 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030705 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047851 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25487516 | We demonstrate for the first time that the high-affinity, non-peptide AT(2) receptor agonist, Compound 21 (C21), penetrates the cell membrane of quiescent SK-UT-1 cells, activates intracellular AT(2) receptors and induces rapid cell death; approximately 70% of cells died within 24 h |
| 25487516 | All quiescent SK-UT-1 cells died within 5 days after treatment with a single dose of C21 |
| 25487516 | C21 was devoid of cytotoxic effects in proliferating SK-UT-1 cells and in quiescent HutSMC |
| 15561193 | The formation of these compounds is attributed to the involvement of enzymatic processes acting specifically on the C-21 or C-22 allylic carbon and the omega15 double bond of methyl and ethyl alkenones respectively |
| 15561193 | The structures of these compounds indicate that they are derivatives of methyl and ethyl alkenones with an additional carbonyl group on the C-21 or C-22 carbon respectively and without the omega15 double bond |
| 15561193 | We propose that these compounds are formed by an initial regiospecific lipoxygenase-catalyzed peroxidation of methyl and ethyl alkenones on their C-21 or C-22 allylic carbon, respectively |
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