HCSGD entry for PPCS
1. General information
| Official gene symbol | PPCS |
|---|---|
| Entrez ID | 79717 |
| Gene full name | phosphopantothenoylcysteine synthetase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004632 | Phosphopantothenate--cysteine ligase activity | IDA TAS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0009108 | Coenzyme biosynthetic process | TAS | biological_process |
| GO:0015937 | Coenzyme A biosynthetic process | IDA IEA | biological_process |
| GO:0015939 | Pantothenate metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8171218115 | 0.1392843357 | 0.9999902473 | 0.7186572129 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2318061752 |
| GSE13712_SHEAR | Down | -0.0688469923 |
| GSE13712_STATIC | Up | 0.1388152689 |
| GSE19018 | Down | -1.1121447209 |
| GSE19899_A1 | Down | -0.3552580863 |
| GSE19899_A2 | Up | 0.1604054859 |
| PubMed_21979375_A1 | Down | -0.0991461563 |
| PubMed_21979375_A2 | Down | -0.2812554327 |
| GSE35957 | Up | 0.1846125278 |
| GSE36640 | Down | -0.1775330445 |
| GSE54402 | Down | -0.4154222644 |
| GSE9593 | Down | -0.1087865596 |
| GSE43922 | Up | 0.0207850807 |
| GSE24585 | Up | 0.5051936354 |
| GSE37065 | Down | -0.0305419865 |
| GSE28863_A1 | Down | -0.0837295375 |
| GSE28863_A2 | Up | 0.0786194149 |
| GSE28863_A3 | Down | -0.1060518409 |
| GSE28863_A4 | Down | -0.1244893523 |
| GSE48662 | Up | 0.1169513399 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019904 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028370 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044998 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
