HCSGD entry for HECTD3
1. General information
| Official gene symbol | HECTD3 |
|---|---|
| Entrez ID | 79654 |
| Gene full name | HECT domain containing E3 ubiquitin protein ligase 3 |
| Other gene symbols | RP11-69J16.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IDA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0019905 | Syntaxin binding | IEA | molecular_function |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0224582767 | 0.5649364424 | 0.3580559055 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2665487671 |
| GSE13712_SHEAR | Up | 0.0556416486 |
| GSE13712_STATIC | Up | 0.1264335361 |
| GSE19018 | Up | 0.3548780732 |
| GSE19899_A1 | Up | 0.0979767221 |
| GSE19899_A2 | Up | 0.6753376567 |
| PubMed_21979375_A1 | Up | 1.6716881595 |
| PubMed_21979375_A2 | Up | 3.0316570113 |
| GSE35957 | Down | -1.2825931308 |
| GSE36640 | Down | -0.2394615385 |
| GSE54402 | Up | 0.0066123162 |
| GSE9593 | Down | -0.1316970282 |
| GSE43922 | Up | 0.2380403979 |
| GSE24585 | Up | 0.1655468090 |
| GSE37065 | Down | -0.0867812120 |
| GSE28863_A1 | Up | 0.2168700247 |
| GSE28863_A2 | Up | 0.6571000158 |
| GSE28863_A3 | Down | -0.5039043859 |
| GSE28863_A4 | Down | -0.3512125418 |
| GSE48662 | Up | 0.0252893555 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023327 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025780 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029557 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039878 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041762 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
