HCSGD entry for SRD5A3
1. General information
| Official gene symbol | SRD5A3 |
|---|---|
| Entrez ID | 79644 |
| Gene full name | steroid 5 alpha-reductase 3 |
| Other gene symbols | CDG1P CDG1Q KRIZI SRD5A2L SRD5A2L1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003865 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006486 | Protein glycosylation | IEA | biological_process |
| GO:0006488 | Dolichol-linked oligosaccharide biosynthetic process | IMP | biological_process |
| GO:0006629 | Lipid metabolic process | IEA | biological_process |
| GO:0006702 | Androgen biosynthetic process | TAS | biological_process |
| GO:0008202 | Steroid metabolic process | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016095 | Polyprenol catabolic process | IDA | biological_process |
| GO:0016627 | Oxidoreductase activity, acting on the CH-CH group of donors | IEA | molecular_function |
| GO:0016628 | Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | IDA | molecular_function |
| GO:0019348 | Dolichol metabolic process | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047751 | Cholestenone 5-alpha-reductase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0016557236 | 0.6501928878 | 0.1092238095 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4807117308 |
| GSE13712_SHEAR | Up | 0.0221845355 |
| GSE13712_STATIC | Up | 0.2248881431 |
| GSE19018 | Up | 0.7884571902 |
| GSE19899_A1 | Up | 0.4589728487 |
| GSE19899_A2 | Up | 2.0194050081 |
| PubMed_21979375_A1 | Up | 2.5426950741 |
| PubMed_21979375_A2 | Up | 2.1013883772 |
| GSE35957 | Up | 0.4006343347 |
| GSE36640 | Up | 0.1327795208 |
| GSE54402 | Up | 1.3275519094 |
| GSE9593 | Up | 0.8655759685 |
| GSE43922 | Up | 0.4501426809 |
| GSE24585 | Down | -0.0562478666 |
| GSE37065 | Up | 0.0149457657 |
| GSE28863_A1 | Down | -0.5038714646 |
| GSE28863_A2 | Up | 0.0066680301 |
| GSE28863_A3 | Down | -0.5248473645 |
| GSE28863_A4 | Down | -0.6827137713 |
| GSE48662 | Down | -0.0091385943 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Spironolactone | DB00421 | APRD01234 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-100-5p | MIMAT0000098 | MIRT048534 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
