HCSGD entry for HMBOX1
1. General information
| Official gene symbol | HMBOX1 |
|---|---|
| Entrez ID | 79618 |
| Gene full name | homeobox containing 1 |
| Other gene symbols | HNF1LA HOT1 PBHNF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3162831237 | 0.5073292922 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0657731341 |
| GSE13712_SHEAR | Down | -0.4735151760 |
| GSE13712_STATIC | Down | -0.3750748742 |
| GSE19018 | Up | 0.1602689333 |
| GSE19899_A1 | Up | 0.0643160498 |
| GSE19899_A2 | Up | 0.0587988669 |
| PubMed_21979375_A1 | Up | 0.1114685495 |
| PubMed_21979375_A2 | Up | 0.4330516554 |
| GSE35957 | Down | -0.3006594581 |
| GSE36640 | Up | 0.0026131359 |
| GSE54402 | Down | -0.1387938578 |
| GSE9593 | Down | -0.2463295758 |
| GSE43922 | Up | 0.0959826798 |
| GSE24585 | Up | 0.1020926638 |
| GSE37065 | Up | 0.0578232417 |
| GSE28863_A1 | Up | 0.5917049262 |
| GSE28863_A2 | Up | 0.5721791329 |
| GSE28863_A3 | Down | -0.0902663870 |
| GSE28863_A4 | Down | -0.2726294417 |
| GSE48662 | Up | 0.2221960979 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30c-1-3p | MIMAT0004674 | MIRT006274 | Luciferase reporter assay//Western blot | Functional MTI | 22320217 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016719 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
