HCSGD entry for CERS4
1. General information
| Official gene symbol | CERS4 |
|---|---|
| Entrez ID | 79603 |
| Gene full name | ceramide synthase 4 |
| Other gene symbols | LASS4 Trh1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0031965 | Nuclear membrane | IEA | cellular_component |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046513 | Ceramide biosynthetic process | IEA | biological_process |
| GO:0050291 | Sphingosine N-acyltransferase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5300804529 | 0.5660777022 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0306580548 |
| GSE13712_SHEAR | Down | -0.5806315372 |
| GSE13712_STATIC | Down | -0.1233343225 |
| GSE19018 | Up | 0.0728271336 |
| GSE19899_A1 | Up | 0.0564143589 |
| GSE19899_A2 | Down | -0.2118925859 |
| PubMed_21979375_A1 | Up | 0.0484104312 |
| PubMed_21979375_A2 | Up | 0.1228787245 |
| GSE35957 | Up | 0.1624289033 |
| GSE36640 | Down | -0.0649621427 |
| GSE54402 | Up | 0.0614926385 |
| GSE9593 | Up | 0.1467498715 |
| GSE43922 | Down | -0.0807656305 |
| GSE24585 | Up | 0.1961478015 |
| GSE37065 | Up | 0.0979552403 |
| GSE28863_A1 | Down | -0.2448160525 |
| GSE28863_A2 | Up | 0.0413925200 |
| GSE28863_A3 | Up | 0.4098069418 |
| GSE28863_A4 | Up | 0.1282898814 |
| GSE48662 | Up | 0.1017903761 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021339 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22230369 | We also demonstrated that upregulation of CerS4 and 6 led to the inhibition of cell proliferation and induction of apoptosis, whereas upregulation of CerS2 increased cell proliferation |
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