HCSGD entry for CALCA

1. General information

Official gene symbolCALCA
Entrez ID796
Gene full namecalcitonin-related polypeptide alpha
Other gene symbolsCALC1 CGRP CGRP-I CGRP1 CT KC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001935Endothelial cell proliferationIDAbiological_process
GO:0001944Vasculature developmentIDAbiological_process
GO:0001976Neurological system process involved in regulation of systemic arterial blood pressureIDAbiological_process
GO:0001984Vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressureIEAbiological_process
GO:0002027Regulation of heart rateIEAbiological_process
GO:0002031G-protein coupled receptor internalizationIDAbiological_process
GO:0002548Monocyte chemotaxisIDAbiological_process
GO:0005102Receptor bindingIDAmolecular_function
GO:0005179Hormone activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007159Leukocyte cell-cell adhesionIDAbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007190Activation of adenylate cyclase activityIDAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDAbiological_process
GO:0007218Neuropeptide signaling pathwayIEAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007566Embryo implantationIDAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007631Feeding behaviorIEAbiological_process
GO:0008217Regulation of blood pressureNASbiological_process
GO:0009408Response to heatIEAbiological_process
GO:0010523Negative regulation of calcium ion transport into cytosolIDAbiological_process
GO:0030279Negative regulation of ossificationIEAbiological_process
GO:0030819Positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0031623Receptor internalizationIDAbiological_process
GO:0031645Negative regulation of neurological system processIEAbiological_process
GO:0031716Calcitonin receptor bindingIPImolecular_function
GO:0032147Activation of protein kinase activityIDAbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0032730Positive regulation of interleukin-1 alpha productionIDAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043195Terminal boutonIEAcellular_component
GO:0043542Endothelial cell migrationIDAbiological_process
GO:0045651Positive regulation of macrophage differentiationIDAbiological_process
GO:0045671Negative regulation of osteoclast differentiationIDAbiological_process
GO:0045762Positive regulation of adenylate cyclase activityIDAbiological_process
GO:0045776Negative regulation of blood pressureIDAbiological_process
GO:0045778Positive regulation of ossificationIEAbiological_process
GO:0045779Negative regulation of bone resorptionIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045909Positive regulation of vasodilationIDAbiological_process
GO:0045986Negative regulation of smooth muscle contractionIEAbiological_process
GO:0048265Response to painIEAbiological_process
GO:0050727Regulation of inflammatory responseIEAbiological_process
GO:0050965Detection of temperature stimulus involved in sensory perception of painIEAbiological_process
GO:0051480Cytosolic calcium ion homeostasisIDAbiological_process
GO:0051482Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61527716650.92860172870.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1657668247
GSE13712_SHEARDown-0.1055063765
GSE13712_STATICUp0.0257961782
GSE19018Up0.0913666377
GSE19899_A1Down-0.0474369767
GSE19899_A2Up0.1162491026
PubMed_21979375_A1Up0.0338661914
PubMed_21979375_A2Up0.0750740070
GSE35957Up0.1726416592
GSE36640Down-0.0021390481
GSE54402Up0.0172826346
GSE9593Up0.1421095343
GSE43922Up0.0565901516
GSE24585Up0.1020642533
GSE37065Down-0.0103802380
GSE28863_A1Down-0.0485967254
GSE28863_A2Down-0.0606663427
GSE28863_A3Up0.2019147261
GSE28863_A4Up0.0563008838
GSE48662Up0.0202678256

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

OlcegepantDB04869 -
MK-0974DB05760 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.