HCSGD entry for MUL1

1. General information

Official gene symbolMUL1
Entrez ID79594
Gene full namemitochondrial E3 ubiquitin protein ligase 1
Other gene symbolsC1orf166 GIDE MAPL MULAN RNF218 RP11-401M16.2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000266Mitochondrial fissionIMPbiological_process
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0004871Signal transducer activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005777PeroxisomeIDAcellular_component
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0007257Activation of JUN kinase activityIDAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010637Negative regulation of mitochondrial fusionIDAbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0016925Protein sumoylationIEAbiological_process
GO:0019789SUMO ligase activityIDAmolecular_function
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0031307Integral component of mitochondrial outer membraneIDAcellular_component
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0033235Positive regulation of protein sumoylationIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0045824Negative regulation of innate immune responseIMPbiological_process
GO:0050689Negative regulation of defense response to virus by hostIMPbiological_process
GO:0050821Protein stabilizationIMPbiological_process
GO:0051646Mitochondrion localizationIMPbiological_process
GO:0051898Negative regulation of protein kinase B signalingIDAbiological_process
GO:0060339Negative regulation of type I interferon-mediated signaling pathwayIMPbiological_process
GO:0071360Cellular response to exogenous dsRNAIDAbiological_process
GO:0071650Negative regulation of chemokine (C-C motif) ligand 5 productionIMPbiological_process
GO:0090141Positive regulation of mitochondrial fissionIDAbiological_process
GO:1901028Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05403578510.72138210550.50696949391.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3380714569
GSE13712_SHEARUp0.1560443030
GSE13712_STATICUp0.3870273504
GSE19018Down-0.4945270020
GSE19899_A1Down-0.0467844492
GSE19899_A2Up0.1301802901
PubMed_21979375_A1Up0.7178169634
PubMed_21979375_A2Up0.8747286772
GSE35957Up0.2048076110
GSE36640Up0.3943681883
GSE54402Up0.1378076604
GSE9593Up0.3527727255
GSE43922Up0.3015463247
GSE24585Down-0.1220816367
GSE37065Up0.0434591216
GSE28863_A1Up0.0877256641
GSE28863_A2Up0.4363557434
GSE28863_A3Down-0.9104525884
GSE28863_A4Down-0.1954373455
GSE48662Up0.3986505186

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.