HCSGD entry for STL
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
Not in the Gene ontology
4. Expression levels in datasets
Individual experiment result ( "-" represent NA in the specific microarray platform )
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles:
1 abstracts the gene occurs . PubMed ID of the article Sentenece the gene occurs 28096886 Fermented Chinese formula Shuan-Tong-Ling (STL), composed of fourteen medicinal herbs, was an experiential formula by Dr 28096886 In this study, we aimed to investigate the protective effects of fermented STL on hydrogen peroxide- (H2O2-) induced injury in rat brain microvascular endothelial cells (BMECs) and the possible mechanisms 28096886 Cultured BMECs were treated with H2O2, STL, or nicotinamide (NAM, a SIRT1 inhibitor) 28096886 Cell proliferation significantly increased with STL treatment in a dose-dependent manner 28096886 With STL treatment, the reduced ROS level was accompanied by increased SOD and GSH activity 28096886 Further assays showed upregulation of SIRT1 and PGC-1alpha and downregulation of p21 after STL treatment 28096886 The results revealed that STL could protect BMECs against oxidative stress injury at least partially through the SIRT1 pathway
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