HCSGD entry for BHLHE41

1. General information

Official gene symbolBHLHE41
Entrez ID79365
Gene full namebasic helix-loop-helix family, member e41
Other gene symbolsBHLHB3 DEC2 SHARP1 hDEC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingISSmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionISSmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingISSmolecular_function
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptionISSmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityISSmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0008283Cell proliferationNASbiological_process
GO:0009887Organ morphogenesisNASbiological_process
GO:0010832Negative regulation of myotube differentiationISSbiological_process
GO:0010944Negative regulation of transcription by competitive promoter bindingISSbiological_process
GO:0030154Cell differentiationNASbiological_process
GO:0032922Circadian regulation of gene expressionIEAbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0042826Histone deacetylase bindingISSmolecular_function
GO:0043425BHLH transcription factor bindingIPI ISSmolecular_function
GO:0043426MRF bindingISSmolecular_function
GO:0046982Protein heterodimerization activityIPI ISSmolecular_function
GO:0070888E-box bindingIDA ISSmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01824282510.84785577300.33024030261.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5323234398
GSE13712_SHEARUp0.0206461002
GSE13712_STATICUp0.1703281811
GSE19018Up0.1396198517
GSE19899_A1Up0.3015393113
GSE19899_A2Up1.2475529822
PubMed_21979375_A1Up0.4123137996
PubMed_21979375_A2Up0.9213100861
GSE35957Down-0.1884565295
GSE36640Up0.1399192313
GSE54402Up0.1266662234
GSE9593Up0.6598689254
GSE43922Up0.5094516442
GSE24585Down-0.1866576006
GSE37065Up0.9807156136
GSE28863_A1Down-0.2472824625
GSE28863_A2Up0.3349454533
GSE28863_A3Up0.1649819021
GSE28863_A4Down-0.1578854207
GSE48662Up0.6828321300

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018496MicroarrayFunctional MTI (Weak)18185580
hsa-miR-186-5pMIMAT0000456MIRT044939CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.