HCSGD entry for BRCC3
1. General information
| Official gene symbol | BRCC3 |
|---|---|
| Entrez ID | 79184 |
| Gene full name | BRCA1/BRCA2-containing complex, subunit 3 |
| Other gene symbols | BRCC36 C6.1A CXorf53 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IDA | cellular_component |
| GO:0000152 | Nuclear ubiquitin ligase complex | IDA | cellular_component |
| GO:0004221 | Ubiquitin thiolesterase activity | IMP | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006302 | Double-strand break repair | IMP | biological_process |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008237 | Metallopeptidase activity | IMP | molecular_function |
| GO:0010165 | Response to X-ray | IDA | biological_process |
| GO:0010212 | Response to ionizing radiation | IMP | biological_process |
| GO:0030234 | Enzyme regulator activity | IDA | molecular_function |
| GO:0031572 | G2 DNA damage checkpoint | IMP | biological_process |
| GO:0031593 | Polyubiquitin binding | IDA | molecular_function |
| GO:0045739 | Positive regulation of DNA repair | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050790 | Regulation of catalytic activity | IDA | biological_process |
| GO:0070531 | BRCA1-A complex | IDA | cellular_component |
| GO:0070536 | Protein K63-linked deubiquitination | IDA | biological_process |
| GO:0070537 | Histone H2A K63-linked deubiquitination | IDA IMP | biological_process |
| GO:0070552 | BRISC complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4335431747 | 0.6720361270 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2193444843 |
| GSE13712_SHEAR | Up | 0.2640427191 |
| GSE13712_STATIC | Up | 0.2181786982 |
| GSE19018 | Up | 0.0584521003 |
| GSE19899_A1 | Down | -0.0506082978 |
| GSE19899_A2 | Up | 0.0126107569 |
| PubMed_21979375_A1 | Up | 0.0545360968 |
| PubMed_21979375_A2 | Down | -0.4129820565 |
| GSE35957 | Up | 0.1048851528 |
| GSE36640 | Down | -0.3475027368 |
| GSE54402 | Up | 0.2079792990 |
| GSE9593 | Up | 0.2307992168 |
| GSE43922 | Up | 0.0531988701 |
| GSE24585 | Down | -0.1585545346 |
| GSE37065 | Up | 0.1836511367 |
| GSE28863_A1 | Up | 0.0914587441 |
| GSE28863_A2 | Up | 0.1093227698 |
| GSE28863_A3 | Down | -0.0588252826 |
| GSE28863_A4 | Down | -0.0583181686 |
| GSE48662 | Up | 0.2208213665 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041195 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049186 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
