HCSGD entry for ALDH5A1
1. General information
| Official gene symbol | ALDH5A1 |
|---|---|
| Entrez ID | 7915 |
| Gene full name | aldehyde dehydrogenase 5 family, member A1 |
| Other gene symbols | SSADH SSDH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004777 | Succinate-semialdehyde dehydrogenase (NAD+) activity | IDA ISS | molecular_function |
| GO:0005739 | Mitochondrion | IDA ISS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006006 | Glucose metabolic process | ISS | biological_process |
| GO:0006083 | Acetate metabolic process | ISS | biological_process |
| GO:0006105 | Succinate metabolic process | ISS | biological_process |
| GO:0006536 | Glutamate metabolic process | ISS | biological_process |
| GO:0006541 | Glutamine metabolic process | ISS | biological_process |
| GO:0006650 | Glycerophospholipid metabolic process | ISS | biological_process |
| GO:0006678 | Glucosylceramide metabolic process | IEA | biological_process |
| GO:0006681 | Galactosylceramide metabolic process | ISS | biological_process |
| GO:0006749 | Glutathione metabolic process | ISS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007269 | Neurotransmitter secretion | TAS | biological_process |
| GO:0007417 | Central nervous system development | IMP | biological_process |
| GO:0009013 | Succinate-semialdehyde dehydrogenase [NAD(P)+] activity | IEA | molecular_function |
| GO:0009450 | Gamma-aminobutyric acid catabolic process | IDA IEA IMP | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0022904 | Respiratory electron transport chain | ISS | biological_process |
| GO:0042135 | Neurotransmitter catabolic process | ISS | biological_process |
| GO:0042803 | Protein homodimerization activity | IC | molecular_function |
| GO:0046459 | Short-chain fatty acid metabolic process | ISS | biological_process |
| GO:0051289 | Protein homotetramerization | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8430418297 | 0.1995546864 | 0.9999902473 | 0.8640366672 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0086468058 |
| GSE13712_SHEAR | Down | -0.2011424846 |
| GSE13712_STATIC | Down | -0.4378550922 |
| GSE19018 | Up | 0.1548408493 |
| GSE19899_A1 | Up | 0.0600398193 |
| GSE19899_A2 | Down | -0.2848480788 |
| PubMed_21979375_A1 | Down | -0.3040403786 |
| PubMed_21979375_A2 | Up | 0.1113417454 |
| GSE35957 | Down | -0.0896465985 |
| GSE36640 | Up | 0.0066667909 |
| GSE54402 | Down | -0.1056019698 |
| GSE9593 | Up | 0.4166478318 |
| GSE43922 | Down | -0.1819754670 |
| GSE24585 | Down | -0.3194251765 |
| GSE37065 | Up | 0.1388939914 |
| GSE28863_A1 | Down | -0.2602272442 |
| GSE28863_A2 | Down | -0.0123872212 |
| GSE28863_A3 | Up | 0.2192460223 |
| GSE28863_A4 | Up | 0.0785646967 |
| GSE48662 | Down | -0.1163090016 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| Chlormerodrin | DB00534 | APRD00864 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020822 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024624 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026627 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030518 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047973 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
