HCSGD entry for DHX58

1. General information

Official gene symbolDHX58
Entrez ID79132
Gene full nameDEXH (Asp-Glu-X-His) box polypeptide 58
Other gene symbolsD11LGP2 D11lgp2e LGP2 RLR-3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIEAmolecular_function
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0003727Single-stranded RNA bindingIDAmolecular_function
GO:0004386Helicase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDA IEAcellular_component
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0009615Response to virusIEA ISSbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016787Hydrolase activityIEAmolecular_function
GO:0032480Negative regulation of type I interferon productionIDA IEAbiological_process
GO:0032481Positive regulation of type I interferon productionIEA ISSbiological_process
GO:0039534Negative regulation of MDA-5 signaling pathwayIMPbiological_process
GO:0039536Negative regulation of RIG-I signaling pathwayIDA IEA IMPbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045088Regulation of innate immune responseIDAbiological_process
GO:0045824Negative regulation of innate immune responseIDA IEAbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:1900245Positive regulation of MDA-5 signaling pathwayIEA ISSbiological_process
GO:1900246Positive regulation of RIG-I signaling pathwayIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04952585010.70242113520.48826498131.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0330175522
GSE13712_SHEARUp1.2745216283
GSE13712_STATICUp1.2297433427
GSE19018Up0.0224746617
GSE19899_A1Down-0.1497269107
GSE19899_A2Up0.0341257351
PubMed_21979375_A1Down-0.0510654432
PubMed_21979375_A2Down-0.1597547062
GSE35957Down-0.9984668565
GSE36640Down-0.0938522337
GSE54402Down-0.0438808623
GSE9593Up0.2809430197
GSE43922Down-0.0536902130
GSE24585Up0.6556238634
GSE37065Up0.8596591631
GSE28863_A1Up0.1340684203
GSE28863_A2Up0.4125560917
GSE28863_A3Down-0.1060929041
GSE28863_A4Up0.1352195706
GSE48662Up0.1134525279

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.