HCSGD entry for DEK
1. General information
| Official gene symbol | DEK |
|---|---|
| Entrez ID | 7913 |
| Gene full name | DEK oncogene |
| Other gene symbols | D6S231E |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0019079 | Viral genome replication | TAS | biological_process |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:2000779 | Regulation of double-strand break repair | IMP | biological_process |
| GO:2001032 | Regulation of double-strand break repair via nonhomologous end joining | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9950202310 | 0.0012229930 | 0.9999902473 | 0.0663719588 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6938637887 |
| GSE13712_SHEAR | Down | -0.1569931826 |
| GSE13712_STATIC | Down | -0.3282236592 |
| GSE19018 | Up | 0.2205997235 |
| GSE19899_A1 | Down | -1.4057396185 |
| GSE19899_A2 | Down | -1.8251120933 |
| PubMed_21979375_A1 | Down | -1.6281410696 |
| PubMed_21979375_A2 | Down | -2.1101230550 |
| GSE35957 | Down | -0.1176629092 |
| GSE36640 | Down | -1.7752097512 |
| GSE54402 | Down | -0.1613077829 |
| GSE9593 | Down | -0.7777421632 |
| GSE43922 | Down | -1.2383346066 |
| GSE24585 | Up | 0.0241975715 |
| GSE37065 | Down | -0.0642469126 |
| GSE28863_A1 | Down | -0.1753861621 |
| GSE28863_A2 | Up | 0.1675249084 |
| GSE28863_A3 | Up | 0.0368848462 |
| GSE28863_A4 | Down | -0.1063649427 |
| GSE48662 | Down | -0.8255391476 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-374b-5p | MIMAT0004955 | MIRT016065 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020832 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024668 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026606 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044904 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT048732 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25255445 | Microarray analysis revealed that in fibroblasts, EZH2 antagonizes a subset of p53 target genes previously associated with the senescent cell phenotype, including DEK and RacGAP1 |
| 22390170 | Silencing of the DEK gene induces apoptosis and senescence in CaSki cervical carcinoma cells via the up-regulation of NF-kappaB p65 |
| 22390170 | The human DEK proto-oncogene has been found to play an important role in autoimmune disease, viral infection and human carcinogenesis |
| 22390170 | In the present study, DEK and IkappaBalpha [inhibitor of NF-kappaB (nuclear factor kappaB) alpha] shRNAs (short hairpin RNAs) were constructed and transfected into CaSki cells using Lipofectamine |
| 22390170 | Following the silencing of DEK and IkappaBalpha, cell proliferation was inhibited, apoptosis was increased, the cell cycle was blocked in the G0/G1-phase with a corresponding decrease in the G2/M-phase, and cell senescence was induced |
| 19223548 | Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo |
| 19223548 | High levels of expression of the human DEK gene have been correlated with numerous human malignancies |
| 19223548 | Intracellular DEK functions have been described in vitro and include DNA supercoiling, DNA replication, RNA splicing, and transcription |
| 19223548 | We have shown that DEK also suppresses cellular senescence, apoptosis, and differentiation, thus promoting cell growth and survival in monolayer and organotypic epithelial raft models |
| 19223548 | Such functions are likely to contribute to cancer, but direct evidence to implicate DEK as an oncogene has remained elusive |
| 19223548 | Here, we show that in line with an early role in tumorigenesis, murine papilloma formation in a classical chemical carcinogenesis model was reduced in DEK knockout mice |
| 19223548 | Additionally, human papillomavirus E6/E7, hRas, and DEK cooperated in the transformation of keratinocytes in soft agar and xenograft establishment, thus also implicating DEK in tumor promotion at later stages |
| 19223548 | Finally, adenoviral DEK depletion via short hairpin RNA expression resulted in cell death in human tumor cells in vitro and in vivo, but did not significantly affect differentiated epithelial cells |
| 19223548 | Taken together, our data uncover oncogenic DEK activities as postulated from its frequent up-regulation in human malignancies, and suggest that the targeted suppression of DEK may become a strategic approach to the treatment of cancer |
| 16894028 | Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions |
| 16894028 | Mechanisms of intracellular DEK functions, however, have remained relatively unexplored |
| 16894028 | We have recently demonstrated that DEK expression is induced by the high-risk human papillomavirus (HPV) E7 protein in a manner which is dependent upon retinoblastoma protein function and have implicated DEK in the inhibition of cellular senescence |
| 16894028 | Additionally, overexpression of DEK resulted in significant life span extension of primary human keratinocytes |
| 16894028 | In order to determine whether DEK expression is required for cellular proliferation and/or survival, we monitored cellular responses to the knockdown of DEK in cancer and primary cells |
| 16894028 | The results indicate that DEK expression protects both HPV-positive cancer and primary human cells from apoptotic cell death |
| 16894028 | Cell death in response to DEK depletion was accompanied by increased protein stability and transcriptional activity of the p53 tumor suppressor and consequent upregulation of known p53 target genes such as p21CIP and Bax |
| 16894028 | Consistent with a possible role for p53 in DEK-mediated cell death inhibition, the p53-negative human osteosarcoma cell line SAOS-2 was resistant to the knockdown of DEK |
| 16894028 | Finally, expression of a dominant negative p53 miniprotein inhibited DEK RNA interference-induced p53 transcriptional induction, as well as cell death, thus directly implicating p53 activation in the observed apoptotic phenotype |
| 16254365 | The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7 |
| 16254365 | The human DEK proto-oncogene is a nucleic acid binding protein with suspected roles in human carcinogenesis, autoimmune disease, and viral infection |
| 16254365 | Intracellular DEK functions, however, are poorly understood |
| 16254365 | We report here the specific repression of DEK message and protein levels in senescing human papillomavirus type 16- (HPV16-) and HPV18-positive cancer cell lines as well as in primary cells undergoing replicative senescence |
| 16254365 | Cervical cancer cell senescence was partially overcome by DEK overexpression, and DEK overexpression was sufficient for extending the life span of primary keratinocytes, supporting critical roles for this molecule as a senescence regulator |
| 16254365 | In order to determine whether DEK is a bona fide HPV oncogene target in primary cells, DEK expression was monitored in human keratinocytes transduced with HPV E6 and/or E7 |
| 16254365 | The results identify high-risk HPV E7 as a positive DEK regulator, an activity that is not shared by low-risk HPV E7 protein |
| 16254365 | Experiments in mouse embryo fibroblasts recapitulated the observed E7-mediated DEK induction and demonstrated that both basal and E7-induced regulation of DEK expression are controlled by the retinoblastoma protein family |
| 16254365 | Taken together, our results suggest that DEK upregulation may be a common event in human carcinogenesis and may reflect its senescence inhibitory function |
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