HCSGD entry for WDR77
1. General information
| Official gene symbol | WDR77 |
|---|---|
| Entrez ID | 79084 |
| Gene full name | WD repeat domain 77 |
| Other gene symbols | MEP-50 MEP50 Nbla10071 RP11-552M11.3 p44 p44/Mep50 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000387 | Spliceosomal snRNP assembly | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IGI | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IGI | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | IGI | molecular_function |
| GO:0034660 | NcRNA metabolic process | TAS | biological_process |
| GO:0034709 | Methylosome | IDA | cellular_component |
| GO:0060528 | Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development | IEA | biological_process |
| GO:0060770 | Negative regulation of epithelial cell proliferation involved in prostate gland development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3044167167 | 0.1794924661 | 0.9999902473 | 0.8203742059 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2129605825 |
| GSE13712_SHEAR | Up | 0.1613067922 |
| GSE13712_STATIC | Up | 0.1040196391 |
| GSE19018 | Down | -0.6442515124 |
| GSE19899_A1 | Up | 0.1119313453 |
| GSE19899_A2 | Up | 0.2818995667 |
| PubMed_21979375_A1 | Up | 0.8067960406 |
| PubMed_21979375_A2 | Up | 0.0375721232 |
| GSE35957 | Down | -0.1012474495 |
| GSE36640 | Down | -0.0332735422 |
| GSE54402 | Up | 0.4041534419 |
| GSE9593 | Down | -0.3664549701 |
| GSE43922 | Up | 0.1773277319 |
| GSE24585 | Down | -0.6773177780 |
| GSE37065 | Down | -0.2531954352 |
| GSE28863_A1 | Down | -0.1049454775 |
| GSE28863_A2 | Up | 0.4747319537 |
| GSE28863_A3 | Down | -0.4714955685 |
| GSE28863_A4 | Down | -0.1075903373 |
| GSE48662 | Down | -0.4821841957 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-27a-3p | MIMAT0000084 | MIRT007024 | Luciferase reporter assay | Functional MTI | 21558443 |
| hsa-miR-1225-5p | MIMAT0005572 | MIRT036545 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038875 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044590 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045318 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047356 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
