HCSGD entry for USP7
1. General information
| Official gene symbol | USP7 |
|---|---|
| Entrez ID | 7874 |
| Gene full name | ubiquitin specific peptidase 7 (herpes virus-associated) |
| Other gene symbols | HAUSP TEF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002039 | P53 binding | IDA | molecular_function |
| GO:0004197 | Cysteine-type endopeptidase activity | IMP | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IDA IEA IMP | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | IMP | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0010216 | Maintenance of DNA methylation | IMP | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016579 | Protein deubiquitination | IDA IMP | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032088 | Negative regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0051090 | Regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6189263820 | 0.4932448083 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0231947684 |
| GSE13712_SHEAR | Down | -0.0723970115 |
| GSE13712_STATIC | Down | -0.0519523978 |
| GSE19018 | Down | -0.2726996573 |
| GSE19899_A1 | Down | -0.0287167662 |
| GSE19899_A2 | Up | 0.0119343592 |
| PubMed_21979375_A1 | Down | -0.6339050390 |
| PubMed_21979375_A2 | Up | 0.0059758959 |
| GSE35957 | Up | 0.1216748873 |
| GSE36640 | Down | -0.0588851397 |
| GSE54402 | Up | 0.0649416273 |
| GSE9593 | Down | -0.0381415339 |
| GSE43922 | Up | 0.0865428932 |
| GSE24585 | Down | -0.5184581237 |
| GSE37065 | Up | 0.0117707174 |
| GSE28863_A1 | Up | 0.2869073432 |
| GSE28863_A2 | Up | 0.4370443018 |
| GSE28863_A3 | Up | 0.0271626717 |
| GSE28863_A4 | Up | 0.2009557511 |
| GSE48662 | Down | -0.1357193051 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT030771 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031560 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-935 | MIMAT0004978 | MIRT036643 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036837 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040289 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050139 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
