HCSGD entry for MAPKAPK3

1. General information

Official gene symbolMAPKAPK3
Entrez ID7867
Gene full namemitogen-activated protein kinase-activated protein kinase 3
Other gene symbols3PK MAPKAP-K3 MAPKAP3 MAPKAPK-3 MK-3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0002224Toll-like receptor signaling pathwayIEA ISS TASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0004708MAP kinase kinase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006950Response to stressTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0032496Response to lipopolysaccharideIEA ISSbiological_process
GO:0034097Response to cytokineIDAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0044351MacropinocytosisIEA ISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03739604120.38676455680.43640155141.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1993128222
GSE13712_SHEARDown-0.0206763423
GSE13712_STATICUp0.3787664837
GSE19018Up0.1149771818
GSE19899_A1Up0.1804230889
GSE19899_A2Up1.1770401647
PubMed_21979375_A1Up1.5613216698
PubMed_21979375_A2Up1.2828453704
GSE35957Down-0.6442309198
GSE36640Down-0.2948259711
GSE54402Up0.5398973376
GSE9593Down-0.1024961041
GSE43922Up0.0805121840
GSE24585Down-0.5444940057
GSE37065Down-0.0578807583
GSE28863_A1Down-0.3187842418
GSE28863_A2Down-0.0301220936
GSE28863_A3Down-0.4011330996
GSE28863_A4Up0.0022903673
GSE48662Up0.1036374625

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONEDB07728 -
2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONEDB08358 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022623MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.