HCSGD entry for PXDN


1. General information

Official gene symbolPXDN
Entrez ID7837
Gene full nameperoxidasin homolog (Drosophila)
Other gene symbolsD2S448 D2S448E MG50 PRG2 PXN VPO
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001960Negative regulation of cytokine-mediated signaling pathwayNASbiological_process
GO:0004601Peroxidase activityIDA IEAmolecular_function
GO:0005152Interleukin-1 receptor antagonist activityNASmolecular_function
GO:0005201Extracellular matrix structural constituentIDAmolecular_function
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0006955Immune responseNASbiological_process
GO:0006979Response to oxidative stressIEAbiological_process
GO:0010469Regulation of receptor activityNASbiological_process
GO:0020037Heme bindingIDA IEAmolecular_function
GO:0030198Extracellular matrix organizationIDAbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0042744Hydrogen peroxide catabolic processIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0055114Oxidation-reduction processIDAbiological_process
GO:1900116Extracellular negative regulation of signal transductionNASbiological_process
GO:2000272Negative regulation of receptor activityNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10489935790.13529304360.67297612670.7095134887

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4594524830
GSE13712_SHEARUp0.1043537295
GSE13712_STATICDown-0.0386278670
GSE19018Up0.8966474788
GSE19899_A1Down-0.1349633107
GSE19899_A2Up0.0630845114
PubMed_21979375_A1Down-0.3207935200
PubMed_21979375_A2Up0.0550572379
GSE35957Down-0.4582824654
GSE36640Up0.1811964674
GSE54402Down-0.3040734429
GSE9593Up0.4689880848
GSE43922Up0.0142018735
GSE24585Down-0.1610796936
GSE37065Down-0.6033599818
GSE28863_A1Up1.2030454945
GSE28863_A2Up1.0460246851
GSE28863_A3Up0.2858913868
GSE28863_A4Down-0.3423907398
GSE48662Down-0.1528857371

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT001602pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-29a-3pMIMAT0000086MIRT006551Luciferase reporter assay//Western blotFunctional MTI20566844
hsa-miR-9-5pMIMAT0000441MIRT021390MicroarrayFunctional MTI (Weak)17612493
hsa-miR-1MIMAT0000416MIRT023628Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1MIMAT0000416MIRT023628ProteomicsFunctional MTI (Weak)18668040
hsa-miR-192-5pMIMAT0000222MIRT026257MicroarrayFunctional MTI (Weak)19074876
hsa-miR-98-5pMIMAT0000096MIRT027510MicroarrayFunctional MTI (Weak)19088304
hsa-miR-324-5pMIMAT0000761MIRT043023CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.