HCSGD entry for SLC30A3

1. General information

Official gene symbolSLC30A3
Entrez ID7781
Gene full namesolute carrier family 30 (zinc transporter), member 3
Other gene symbolsZNT3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005737CytoplasmIDAcellular_component
GO:0005768EndosomeTAScellular_component
GO:0005770Late endosomeIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0008021Synaptic vesicleTAScellular_component
GO:0008324Cation transmembrane transporter activityIEAmolecular_function
GO:0015633Zinc transporting ATPase activityTASmolecular_function
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030672Synaptic vesicle membraneIEAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0043005Neuron projectionIEA ISScellular_component
GO:0051050Positive regulation of transportIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0061088Regulation of sequestering of zinc ionIDAbiological_process
GO:0071577Zinc ion transmembrane transportTASbiological_process
GO:0072511Divalent inorganic cation transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13250678550.62882407960.73771876581.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0485008765
GSE13712_SHEARDown-0.7811784983
GSE13712_STATICDown-1.4068916355
GSE19018Up0.2342003700
GSE19899_A1Up0.2212600462
GSE19899_A2Up0.3067236010
PubMed_21979375_A1Up0.5766460163
PubMed_21979375_A2Up0.1858591640
GSE35957Up0.2694730933
GSE36640Down-0.2343525170
GSE54402Up0.4190305337
GSE9593Down-0.0156271038
GSE43922Up0.1870829709
GSE24585Up0.0760763946
GSE37065Down-0.1100402871
GSE28863_A1Down-0.1019935229
GSE28863_A2Up0.0543391472
GSE28863_A3Up0.3202733535
GSE28863_A4Up0.1374326861
GSE48662Up0.1482570212

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22427991Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells
22427991We found that Ang II-induced senescence is a zinc-dependent pathway mediated by the downregulation of the zinc transporters ZnT3 and ZnT10, which work to reduce cytosolic zinc
22427991Zinc increases Ang II-induced senescence, while the zinc chelator TPEN, as well as overexpression of ZnT3 or ZnT10, decreases ROS and prevents senescence
22427991Consistently, ZnT3 and ZnT10 downregulation by siRNA increases ROS while downregulation of catalase by siRNA induces senescence
22427991These data demonstrate that zinc homeostasis dysfunction by decreased expression of ZnT3 or ZnT10 promotes senescence and that Ang II-induced senescence is a zinc and ROS-dependent process
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