HCSGD entry for ZNF217
1. General information
| Official gene symbol | ZNF217 |
|---|---|
| Entrez ID | 7764 |
| Gene full name | zinc finger protein 217 |
| Other gene symbols | ZABC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000118 | Histone deacetylase complex | IDA | cellular_component |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0209673341 | 0.8861781581 | 0.3488982301 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6959979815 |
| GSE13712_SHEAR | Up | 0.7133451158 |
| GSE13712_STATIC | Up | 0.1120064891 |
| GSE19018 | Up | 0.0396505710 |
| GSE19899_A1 | Up | 0.5188813346 |
| GSE19899_A2 | Up | 0.2104738546 |
| PubMed_21979375_A1 | Up | 0.4319034873 |
| PubMed_21979375_A2 | Up | 0.0931453493 |
| GSE35957 | Down | -0.3836219474 |
| GSE36640 | Down | -0.6797226281 |
| GSE54402 | Up | 0.3511954209 |
| GSE9593 | Down | -0.2950284717 |
| GSE43922 | Up | 0.0423121322 |
| GSE24585 | Up | 0.4050867913 |
| GSE37065 | Up | 0.3002350030 |
| GSE28863_A1 | Up | 0.6179648889 |
| GSE28863_A2 | Up | 0.3158688645 |
| GSE28863_A3 | Down | -0.6577919683 |
| GSE28863_A4 | Up | 0.0665865273 |
| GSE48662 | Up | 0.5216179229 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT007012 | Luciferase reporter assay | Functional MTI | 22815235 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT007012 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020307 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028154 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028190 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT030645 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030903 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031170 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046483 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17266044 | Multiple roles of the candidate oncogene ZNF217 in ovarian epithelial neoplastic progression |
| 17266044 | The transcription factor ZNF217 is often amplified in ovarian cancer, but its role in neoplastic progression is unknown |
| 17266044 | The permanent lines were EGF-independent, but ZNF217-dependent since siRNA to ZNF217 inhibited anchorage independence and arrested growth |
| 17266044 | The results implicate ZNF217 as an ovarian oncogene, which is detrimental to senescing normal OSE cells but contributes to neoplastic progression in OSE with inactivated p53/RB |
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