HCSGD entry for CACNA1A

1. General information

Official gene symbol	CACNA1A
Entrez ID	773
Gene full name	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Other gene symbols	APCA BI CACNL1A4 CAV2.1 EA2 FHM HPCA MHP MHP1 SCA6
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000096	Sulfur amino acid metabolic process	IEA	biological_process
GO:0005216	Ion channel activity	IEA	molecular_function
GO:0005245	Voltage-gated calcium channel activity	IDA IEA ISS	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005634	Nucleus	IDA	cellular_component
GO:0005737	Cytoplasm	IDA	cellular_component
GO:0005886	Plasma membrane	IDA TAS	cellular_component
GO:0005891	Voltage-gated calcium channel complex	IEA	cellular_component
GO:0006006	Glucose metabolic process	IEA	biological_process
GO:0006112	Energy reserve metabolic process	TAS	biological_process
GO:0007204	Positive regulation of cytosolic calcium ion concentration	IDA ISS	biological_process
GO:0007214	Gamma-aminobutyric acid signaling pathway	IEA	biological_process
GO:0007268	Synaptic transmission	TAS	biological_process
GO:0007274	Neuromuscular synaptic transmission	IEA	biological_process
GO:0007416	Synapse assembly	IEA	biological_process
GO:0007628	Adult walking behavior	IEA	biological_process
GO:0008219	Cell death	IDA	biological_process
GO:0008331	High voltage-gated calcium channel activity	IEA	molecular_function
GO:0014051	Gamma-aminobutyric acid secretion	IEA	biological_process
GO:0014056	Regulation of acetylcholine secretion, neurotransmission	IEA	biological_process
GO:0016021	Integral component of membrane	IEA NAS TAS	cellular_component
GO:0016049	Cell growth	IEA	biological_process
GO:0017156	Calcium ion-dependent exocytosis	IEA	biological_process
GO:0017158	Regulation of calcium ion-dependent exocytosis	IEA	biological_process
GO:0019905	Syntaxin binding	IDA	molecular_function
GO:0021522	Spinal cord motor neuron differentiation	IEA	biological_process
GO:0021590	Cerebellum maturation	IEA	biological_process
GO:0021679	Cerebellar molecular layer development	IEA	biological_process
GO:0021702	Cerebellar Purkinje cell differentiation	IEA	biological_process
GO:0021750	Vestibular nucleus development	IEA	biological_process
GO:0030425	Dendrite	IEA	cellular_component
GO:0030644	Cellular chloride ion homeostasis	IEA	biological_process
GO:0032353	Negative regulation of hormone biosynthetic process	IEA	biological_process
GO:0035249	Synaptic transmission, glutamatergic	IEA	biological_process
GO:0042133	Neurotransmitter metabolic process	IEA	biological_process
GO:0042445	Hormone metabolic process	IEA	biological_process
GO:0042995	Cell projection	IDA	cellular_component
GO:0043025	Neuronal cell body	IEA	cellular_component
GO:0043113	Receptor clustering	IEA	biological_process
GO:0043524	Negative regulation of neuron apoptotic process	IEA	biological_process
GO:0044281	Small molecule metabolic process	TAS	biological_process
GO:0046872	Metal ion binding	IEA	molecular_function
GO:0048266	Behavioral response to pain	IEA	biological_process
GO:0048791	Calcium ion-dependent exocytosis of neurotransmitter	IEA	biological_process
GO:0048813	Dendrite morphogenesis	IEA	biological_process
GO:0050770	Regulation of axonogenesis	IEA	biological_process
GO:0050796	Regulation of insulin secretion	TAS	biological_process
GO:0050883	Musculoskeletal movement, spinal reflex action	IEA	biological_process
GO:0050885	Neuromuscular process controlling balance	IEA	biological_process
GO:0051899	Membrane depolarization	TAS	biological_process
GO:0060024	Rhythmic synaptic transmission	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.0099469739	0.9602633411	0.2544104854	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.3575399027
GSE13712_SHEAR	Up	0.4365073299
GSE13712_STATIC	Up	0.1571851303
GSE19018	Up	0.1410956550
GSE19899_A1	Down	-0.1199413496
GSE19899_A2	Up	1.2310208195
PubMed_21979375_A1	Up	1.6157774785
PubMed_21979375_A2	Up	0.6479436356
GSE35957	Up	0.0529821685
GSE36640	Down	-0.0497188607
GSE54402	Up	1.7385275768
GSE9593	Up	0.5730987952
GSE43922	Down	-0.7133135469
GSE24585	Down	-0.0026352157
GSE37065	Up	0.7369391650
GSE28863_A1	Up	0.0522714239
GSE28863_A2	Up	0.0043533945
GSE28863_A3	Up	0.3107550849
GSE28863_A4	Down	-0.0252036228
GSE48662	Down	-0.0419300453

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Pregabalin	DB00230	APRD01198
Verapamil	DB00661	APRD00335
Loperamide	DB00836	APRD00275
Bepridil	DB01244	APRD00727
Spironolactone	DB00421	APRD01234

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for CACNA1A

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )