HCSGD entry for CA4

1. General information

Official gene symbolCA4
Entrez ID762
Gene full namecarbonic anhydrase IV
Other gene symbolsCAIV Car4 RP17
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004089Carbonate dehydratase activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005791Rough endoplasmic reticulumIDAcellular_component
GO:0005793Endoplasmic reticulum-Golgi intermediate compartmentIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005802Trans-Golgi networkIDAcellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0006730One-carbon metabolic processIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009986Cell surfaceIDAcellular_component
GO:0015701Bicarbonate transportIMP TASbiological_process
GO:0016020MembraneTAScellular_component
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016324Apical plasma membraneIDA IEAcellular_component
GO:0016529Sarcoplasmic reticulumIEAcellular_component
GO:0030658Transport vesicle membraneIDAcellular_component
GO:0030667Secretory granule membraneIDAcellular_component
GO:0031225Anchored component of membraneIEAcellular_component
GO:0031362Anchored component of external side of plasma membraneIDAcellular_component
GO:0031526Brush border membraneIDAcellular_component
GO:0042383SarcolemmaIEAcellular_component
GO:0042493Response to drugIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044459Plasma membrane partIDAcellular_component
GO:0046658Anchored component of plasma membraneIEAcellular_component
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048513Organ developmentIEAbiological_process
GO:0048545Response to steroid hormoneIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35299551310.95864695870.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0762828976
GSE13712_SHEARUp0.1934109587
GSE13712_STATICUp0.1260497924
GSE19018Up0.1554498198
GSE19899_A1Up0.0945552970
GSE19899_A2Down-0.0170315459
PubMed_21979375_A1Up0.3669485360
PubMed_21979375_A2Down-0.0076417253
GSE35957Up0.0952963326
GSE36640Up0.1655109797
GSE54402Down-0.0131379455
GSE9593Down-0.1107269234
GSE43922Up0.0907068136
GSE24585Up0.2536788160
GSE37065Down-0.0698117210
GSE28863_A1Down-0.0581869672
GSE28863_A2Down-0.1037868452
GSE28863_A3Up0.2669622378
GSE28863_A4Up0.0983970253
GSE48662Up0.0419201636

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MethyclothiazideDB00232 APRD01104
TopiramateDB00273 APRD00237
EthoxzolamideDB00311 APRD00732 | DB07727
BendroflumethiazideDB00436 APRD00666
MethazolamideDB00703 APRD00740
HydroflumethiazideDB00774 APRD01020
ChlorothiazideDB00880 APRD00721
ZonisamideDB00909 APRD00004
HydrochlorothiazideDB00999 APRD00092
TrichlormethiazideDB01021 APRD00031
BrinzolamideDB01194 APRD00475
Ellagic AcidDB08846 DB08468

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.