HCSGD entry for CA3
1. General information
| Official gene symbol | CA3 |
|---|---|
| Entrez ID | 761 |
| Gene full name | carbonic anhydrase III, muscle specific |
| Other gene symbols | CAIII Car3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004089 | Carbonate dehydratase activity | IEA | molecular_function |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0006730 | One-carbon metabolic process | IEA | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0015701 | Bicarbonate transport | TAS | biological_process |
| GO:0016151 | Nickel cation binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7325984081 | 0.5247460811 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1514537576 |
| GSE13712_SHEAR | Down | -0.2024106938 |
| GSE13712_STATIC | Down | -0.0668872307 |
| GSE19018 | Up | 0.1603305981 |
| GSE19899_A1 | Down | -0.0430857594 |
| GSE19899_A2 | Down | -0.1027802466 |
| PubMed_21979375_A1 | Up | 0.2360380037 |
| PubMed_21979375_A2 | Down | -0.2179134383 |
| GSE35957 | Down | -0.1858473313 |
| GSE36640 | Down | -0.0232057559 |
| GSE54402 | Up | 0.0900920466 |
| GSE9593 | Down | -0.3531187506 |
| GSE43922 | Up | 0.2043208076 |
| GSE24585 | Up | 0.0875278989 |
| GSE37065 | Down | -0.0092294623 |
| GSE28863_A1 | Up | 0.0481893819 |
| GSE28863_A2 | Up | 0.1676036990 |
| GSE28863_A3 | Up | 0.1505053855 |
| GSE28863_A4 | Up | 0.0648587071 |
| GSE48662 | Down | -0.0440550092 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018185 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT023831 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 14992815 | To explore the molecular mechanisms underlying the increased vulnerability of the aged brain to traumatic brain injury (TBI), we compared the expression of several age-related genes in the CA1, CA3 and dentate gyrus subfields of the young and aged rat hippocampus before and after lateral fluid percussion TBI |
| 14992815 | By quantitative RPA analysis, we found that the expression of p21, known to be induced in senescent cells, was significantly greater in the CA3 region of aged rats, an area that is selectively vulnerable to TBI |
| 3785534 | A precocious and progressive deposition of lipofuscin pigment was found in both CA1 and CA3 neurons in Ammon's horn hippocampal fields after 3 and 6 months of alcohol feeding, respectively |
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