HCSGD entry for CA2

1. General information

Official gene symbolCA2
Entrez ID760
Gene full namecarbonic anhydrase II
Other gene symbolsCA-II CAC CAII Car2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentIEAbiological_process
GO:0002009Morphogenesis of an epitheliumIEAbiological_process
GO:0004089Carbonate dehydratase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005902MicrovillusIEAcellular_component
GO:0006730One-carbon metabolic processIEAbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0009268Response to pHIEAbiological_process
GO:0010043Response to zinc ionIEAbiological_process
GO:0015670Carbon dioxide transportIEAbiological_process
GO:0015701Bicarbonate transportTASbiological_process
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0030424AxonIEAcellular_component
GO:0032849Positive regulation of cellular pH reductionIEAbiological_process
GO:0038166Angiotensin-activated signaling pathwayIDAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0044070Regulation of anion transportIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045177Apical part of cellIDAcellular_component
GO:0045672Positive regulation of osteoclast differentiationIEAbiological_process
GO:0045780Positive regulation of bone resorptionIEAbiological_process
GO:0046903SecretionIEAbiological_process
GO:0051453Regulation of intracellular pHISSbiological_process
GO:2001150Positive regulation of dipeptide transmembrane transportISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02726069680.10251677370.38332142090.6136011824

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6186849683
GSE13712_SHEARUp3.6006134786
GSE13712_STATICUp2.9840992367
GSE19018Up0.1423033145
GSE19899_A1Up0.2027990759
GSE19899_A2Down-0.0463327942
PubMed_21979375_A1Down-0.1779332195
PubMed_21979375_A2Up0.1999048894
GSE35957Down-3.2096415684
GSE36640Up0.0086436101
GSE54402Up0.1508882487
GSE9593Down-1.6640294036
GSE43922Up0.0834578523
GSE24585Down-0.9812160359
GSE37065Down-0.5325824614
GSE28863_A1Down-0.1593616672
GSE28863_A2Up0.0317415538
GSE28863_A3Up0.1621516952
GSE28863_A4Up0.0945293299
GSE48662Down-0.0182314864

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030094SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT030094MicroarrayFunctional MTI (Weak)19088304
hsa-miR-99b-3pMIMAT0004678MIRT038519CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050149CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.