HCSGD entry for ZFX
1. General information
| Official gene symbol | ZFX |
|---|---|
| Entrez ID | 7543 |
| Gene full name | zinc finger protein, X-linked |
| Other gene symbols | ZNF926 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5375135671 | 0.3534836670 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5358588427 |
| GSE13712_SHEAR | Up | 0.1277422266 |
| GSE13712_STATIC | Down | -0.1225548011 |
| GSE19018 | Up | 0.0147611415 |
| GSE19899_A1 | Down | -0.1223134174 |
| GSE19899_A2 | Down | -0.0737755868 |
| PubMed_21979375_A1 | Up | 0.6335244587 |
| PubMed_21979375_A2 | Up | 0.1247967696 |
| GSE35957 | Up | 0.1284695191 |
| GSE36640 | Down | -0.2298544616 |
| GSE54402 | Up | 0.1885325195 |
| GSE9593 | Down | -0.0826305923 |
| GSE43922 | Down | -0.1601856585 |
| GSE24585 | Up | 0.2372316392 |
| GSE37065 | Up | 0.0812254005 |
| GSE28863_A1 | Down | -0.1403166362 |
| GSE28863_A2 | Down | -0.2260190833 |
| GSE28863_A3 | Up | 0.3402346040 |
| GSE28863_A4 | Down | -0.0335040694 |
| GSE48662 | Up | 0.2272159321 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-101-3p | MIMAT0000099 | MIRT027367 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027627 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-484 | MIMAT0002174 | MIRT042023 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24228108 | ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299 |
| 24228108 | ZFX (zinc finger transcription factor, X chromosome-linked) contributes to the maintenance of different types of stem cells and the progression of various cancers |
| 24228108 | We have previously reported that ZFX knockdown inhibits proliferation of glioma in vitro and in vivo |
| 24228108 | Since overexpression of ZFX in lung cancer tissue correlates with lymph node metastasis, we hypothesized that ZFX may play a role in lung cancer |
| 24228108 | In this study, we identified ZFX as a promoter of lung cancer growth and migration in a NSCLC (non-small cell lung carcinoma) cell line H1299 |
| 24228108 | ZFX knockdown also led to decreased proportion of tumor bearing mice and reduced mean tumor volume in a subcutaneous tumor model |
| 24228108 | In addition, western blot showed that ZFX knockdown down regulated a set of proteins involved in proliferation, survival and motility |
| 24228108 | Altogether, these results suggest that ZFX may be a potential therapeutic target for NSCLC |
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