HCSGD entry for ZFP36

1. General information

Official gene symbolZFP36
Entrez ID7538
Gene full nameZFP36 ring finger protein
Other gene symbolsG0S24 GOS24 NUP475 RNF162A TIS11 TTP zfp-36
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA IMPbiological_process
GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayIDAbiological_process
GO:0000289Nuclear-transcribed mRNA poly(A) tail shorteningIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003727Single-stranded RNA bindingTASmolecular_function
GO:0003729MRNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDA IEA TAScellular_component
GO:0006402MRNA catabolic processIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010494Cytoplasmic stress granuleIDAcellular_component
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0017091AU-rich element bindingIDA IMPmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019957C-C chemokine bindingIPImolecular_function
GO:0032680Regulation of tumor necrosis factor productionIDAbiological_process
GO:0035278Negative regulation of translation involved in gene silencing by miRNAIEA ISSbiological_process
GO:0035925MRNA 3'-UTR AU-rich region bindingIEAmolecular_function
GO:0042594Response to starvationIDAbiological_process
GO:0043488Regulation of mRNA stabilityIEAbiological_process
GO:0045638Negative regulation of myeloid cell differentiationIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:0050779RNA destabilizationIEAbiological_process
GO:0060213Positive regulation of nuclear-transcribed mRNA poly(A) tail shorteningIDAbiological_process
GO:00709353'-UTR-mediated mRNA stabilizationIDAbiological_process
GO:007188914-3-3 protein bindingIDAmolecular_function
GO:1900153Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20567307850.01721539080.87427666340.2574145845

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8170640175
GSE13712_SHEARUp0.0436567375
GSE13712_STATICDown-0.0110115823
GSE19018Down-2.0208643297
GSE19899_A1Down-0.6461730554
GSE19899_A2Down-0.6411498932
PubMed_21979375_A1Down-0.3289914824
PubMed_21979375_A2Down-0.0806692643
GSE35957Up0.3621703144
GSE36640Up0.0444447344
GSE54402Down-0.1392141072
GSE9593Down-0.1842149897
GSE43922Down-0.4867116584
GSE24585Up0.6825552185
GSE37065Down-0.3212993337
GSE28863_A1Up1.3255640839
GSE28863_A2Down-0.2476813635
GSE28863_A3Up0.0883934469
GSE28863_A4Up0.3359993168
GSE48662Up0.1767222612

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-346MIMAT0000773MIRT016689Western blot;qRT-PCR;OtherFunctional MTI21611196
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.