HCSGD entry for YES1
1. General information
| Official gene symbol | YES1 |
|---|---|
| Entrez ID | 7525 |
| Gene full name | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
| Other gene symbols | HsT441 P61-YES Yes c-yes |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004713 | Protein tyrosine kinase activity | EXP IEA TAS | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | TAS | molecular_function |
| GO:0005154 | Epidermal growth factor receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0015758 | Glucose transport | IEA | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | EXP TAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0043114 | Regulation of vascular permeability | TAS | biological_process |
| GO:0044325 | Ion channel binding | IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046777 | Protein autophosphorylation | IEA | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1177871130 | 0.6970879602 | 0.7041277765 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1672650670 |
| GSE13712_SHEAR | Down | -0.1235191679 |
| GSE13712_STATIC | Down | -0.0389798271 |
| GSE19018 | Down | -0.3468825400 |
| GSE19899_A1 | Up | 0.8648765872 |
| GSE19899_A2 | Up | 0.5581325973 |
| PubMed_21979375_A1 | Up | 0.7951667682 |
| PubMed_21979375_A2 | Up | 0.4405234741 |
| GSE35957 | Up | 0.0216508172 |
| GSE36640 | Down | -0.1356907846 |
| GSE54402 | Up | 0.2845979056 |
| GSE9593 | Down | -0.1377799876 |
| GSE43922 | Up | 0.5783671558 |
| GSE24585 | Down | -0.0688899267 |
| GSE37065 | Up | 0.0758163601 |
| GSE28863_A1 | Down | -0.1086007863 |
| GSE28863_A2 | Up | 0.0387308030 |
| GSE28863_A3 | Down | -0.1714779856 |
| GSE28863_A4 | Up | 0.0862642150 |
| GSE48662 | Down | -0.8077548485 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Dasatinib | DB01254 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-17-5p | MIMAT0000070 | MIRT000263 | Luciferase reporter assay | Functional MTI | 19734348 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT000627 | qRT-PCR//Luciferase reporter assay//Western blot//Microarray | Functional MTI | 20098684 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT000627 | Reporter assay;Microarray | Functional MTI | 21351259 |
| hsa-miR-519a-3p | MIMAT0002869 | MIRT005569 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 21274007 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021096 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT021309 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT021309 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT021620 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT024970 | Reporter assay | Functional MTI | 21330408 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT025605 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044267 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
