HCSGD entry for XRCC4

1. General information

Official gene symbolXRCC4
Entrez ID7518
Gene full nameX-ray repair complementing defective repair in Chinese hamster cells 4
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000793Condensed chromosomeIDAcellular_component
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002328Pro-B cell differentiationIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolIDAcellular_component
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complexIDAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0006302Double-strand break repairIDA TASbiological_process
GO:0006303Double-strand break repair via nonhomologous end joiningIDA IMP NAS TASbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0010165Response to X-rayIDAbiological_process
GO:0010332Response to gamma radiationIEAbiological_process
GO:0016032Viral processTASbiological_process
GO:0016874Ligase activityIDAmolecular_function
GO:0032807DNA ligase IV complexIDAcellular_component
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0033152Immunoglobulin V(D)J recombinationIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045190Isotype switchingIEAbiological_process
GO:0048146Positive regulation of fibroblast proliferationIEAbiological_process
GO:0050769Positive regulation of neurogenesisIEAbiological_process
GO:0051103DNA ligation involved in DNA repairIDAbiological_process
GO:0051351Positive regulation of ligase activityIDAbiological_process
GO:0070419Nonhomologous end joining complexIDAcellular_component
GO:0071285Cellular response to lithium ionIEAbiological_process
GO:0075713Establishment of integrated proviral latencyTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95322627560.00659110600.99999024730.1636646226

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2746729096
GSE13712_SHEARDown-0.0213983430
GSE13712_STATICDown-0.2245973993
GSE19018Up0.0333101518
GSE19899_A1Down-0.4540266340
GSE19899_A2Down-1.1923451886
PubMed_21979375_A1Down-1.3668833315
PubMed_21979375_A2Down-2.0420524415
GSE35957Up0.0098330766
GSE36640Up0.2242645972
GSE54402Down-0.5269781035
GSE9593Down-0.5488663441
GSE43922Down-0.8266341985
GSE24585Down-0.3585810738
GSE37065Up0.2505742145
GSE28863_A1Down-0.0224936082
GSE28863_A2Up0.3963611523
GSE28863_A3Down-0.4798974376
GSE28863_A4Up0.0503569819
GSE48662Down-0.5140846639

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

S-(Dimethylarsenic)CysteineDB03963 EXPT00832

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26224580Statins also impaired the expression of DNA repair genes, including XRCC4, XRCC6, and Apex1
25678531Genome-wide gene expression analysis revealed age-related impairment of mitosis, telomere and chromosome maintenance and induction of genes associated with DNA repair and non-homologous end-joining, most notably XRCC4 and ligase 4
17347130Non-homologous end joining (NHEJ), the major pathway of double-strand break (DSB) repair in mammalian cells, comprises two subpathways: one that requires the three core factors Ku70/80, DNA-PKcs and XRCC4/LigIV (DNA-PK-dependent NHEJ) and the other that is independent of these factors
17347130Using a cell-free NHEJ assay, we have investigated the ability of three Chinese hamster ovary (CHO) mutants deficient in Ku80 (xrs6), DNA-PKcs (XR-C1) and XRCC4 (XR-1) in comparison with CHO-K1 wild-type cells to rejoin non-compatible DSB ends
16757976In addition, p53S18/23A, but not p53S18A, could completely rescue embryonic lethality of Xrcc4(-/-) mice that is caused by massive p53-dependent neuronal apoptosis
16757976Interestingly, Xrcc4(-/-)p53S18/23A mice fail to develop tumors like the pro-B cell lymphomas uniformly developed in Xrcc4(-/-) p53(-/-) animals, but exhibit developmental defects typical of accelerated ageing
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