HCSGD entry for WT1

1. General information

Official gene symbolWT1
Entrez ID7490
Gene full nameWilms tumor 1
Other gene symbolsAWT1 EWS-WT1 GUD NPHS4 WAGR WIT-2 WT33
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0001570VasculogenesisIEA ISSbiological_process
GO:0001656Metanephros developmentIEAbiological_process
GO:0001657Ureteric bud developmentISSbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIGIbiological_process
GO:0001822Kidney developmentIGIbiological_process
GO:0001823Mesonephros developmentIEAbiological_process
GO:0003156Regulation of organ formationISSbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityISS NASmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmIDAcellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmIBA IEA ISScellular_component
GO:0006309Apoptotic DNA fragmentationIDAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEA ISS NASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007281Germ cell developmentIEA ISSbiological_process
GO:0007356Thorax and anterior abdomen determinationISSbiological_process
GO:0007507Heart developmentIGIbiological_process
GO:0007530Sex determinationIDA IEAbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008380RNA splicingISSbiological_process
GO:0008406Gonad developmentISSbiological_process
GO:0008584Male gonad developmentIEA IEPbiological_process
GO:0009888Tissue developmentIEA ISSbiological_process
GO:0016607Nuclear speckIDAcellular_component
GO:0017148Negative regulation of translationIDAbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030325Adrenal gland developmentIGIbiological_process
GO:0030539Male genitalia developmentISSbiological_process
GO:0030855Epithelial cell differentiationISSbiological_process
GO:0032835Glomerulus developmentIGIbiological_process
GO:0032836Glomerular basement membrane developmentIMPbiological_process
GO:0035802Adrenal cortex formationISSbiological_process
GO:0043010Camera-type eye developmentIEA ISSbiological_process
GO:0043066Negative regulation of apoptotic processIGIbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IGIbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0060231Mesenchymal to epithelial transitionISSbiological_process
GO:0060421Positive regulation of heart growthISSbiological_process
GO:0060539Diaphragm developmentISSbiological_process
GO:0060923Cardiac muscle cell fate commitmentISSbiological_process
GO:0061032Visceral serous pericardium developmentIGIbiological_process
GO:0070742C2H2 zinc finger domain bindingIPImolecular_function
GO:0071320Cellular response to cAMPIEPbiological_process
GO:0071371Cellular response to gonadotropin stimulusIDAbiological_process
GO:0072075Metanephric mesenchyme developmentISSbiological_process
GO:0072112Glomerular visceral epithelial cell differentiationIBA ISSbiological_process
GO:0072166Posterior mesonephric tubule developmentISSbiological_process
GO:0072207Metanephric epithelium developmentIEPbiological_process
GO:0072284Metanephric S-shaped body morphogenesisIGIbiological_process
GO:0072302Negative regulation of metanephric glomerular mesangial cell proliferationISSbiological_process
GO:1900212Negative regulation of mesenchymal cell apoptotic process involved in metanephros developmentIEAbiological_process
GO:2000020Positive regulation of male gonad developmentISSbiological_process
GO:2000195Negative regulation of female gonad developmentISSbiological_process
GO:2001076Positive regulation of metanephric ureteric bud developmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53390433110.89897394100.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1444447793
GSE13712_SHEARDown-0.0636305622
GSE13712_STATICUp0.1527793335
GSE19018Up0.1154510409
GSE19899_A1Up0.1113189124
GSE19899_A2Up0.0850166304
PubMed_21979375_A1Up0.0417675277
PubMed_21979375_A2Up0.0286035148
GSE35957Up0.0754898729
GSE36640Up0.0595172703
GSE54402Up0.3753590579
GSE9593Up0.0722646918
GSE43922Up0.0274089756
GSE24585Down-0.2259272839
GSE37065Down-0.0291639430
GSE28863_A1Down-0.0039829421
GSE28863_A2Down-0.0158733977
GSE28863_A3Up0.3058259333
GSE28863_A4Up0.0144282468
GSE48662Up0.0341374419

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT000816qRT-PCR//proteomics analysisFunctional MTI (Weak)18362358
hsa-miR-15a-5pMIMAT0000068MIRT000817qRT-PCR//proteomics analysisFunctional MTI (Weak)18362358
hsa-miR-212-3pMIMAT0000269MIRT003966MicroarrayFunctional MTI (Weak)17875710
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-15a-5pMIMAT0000068NAhsa-miR-15a{phenotypic analysis of target gene}{overexpression}18362358
hsa-miR-16-5pMIMAT0000069NAhsa-miR-16{phenotypic analysis of target gene}{overexpression}18362358
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27698927The cells consistently harbored concomitant mutations of CTNNB1 (Ser45Pro) and WT1 (Arg413Stop) thorough the cultivation
24490140A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems
24490140The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy
24490140A lysine-arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against A2058 human melanoma cells and B16F10-Nex2 syngeneic murine melanoma
24490140Moreover, the peptide bound to p53 and competed with WT1 protein for binding to p53
22532803Epigenome-wide association scans (EWAS) identified age-related phenotype DMRs (ap-DMRs) associated with LDL (STAT5A), lung function (WT1), and maternal longevity (ARL4A, TBX20)
20972333Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models
20972333Using a combination of functional genomics and mouse genetics, we identified a role for the transcription factor Wilms tumor 1 (WT1) as a critical regulator of senescence and proliferation downstream of oncogenic KRAS signaling
20972333Deletion or suppression of Wt1 led to senescence of mouse primary cells expressing physiological levels of oncogenic Kras but had no effect on wild-type cells, and Wt1 loss decreased tumor burden in a mouse model of Kras-driven lung cancer
20972333In human lung cancer cell lines dependent on oncogenic KRAS, WT1 loss decreased proliferation and induced senescence
20972333Furthermore, WT1 inactivation defined a gene expression signature that was prognostic of survival only in lung cancer patients exhibiting evidence of oncogenic KRAS activation
20972333These findings reveal an unexpected role for WT1 as a key regulator of the genetic network of oncogenic KRAS and provide important insight into the mechanisms that regulate proliferation or senescence in response to oncogenic signals
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