HCSGD entry for WNT7A

1. General information

Official gene symbolWNT7A
Entrez ID7476
Gene full namewingless-type MMTV integration site family, member 7A
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000578Embryonic axis specificationIMPbiological_process
GO:0001502Cartilage condensationIDAbiological_process
GO:0002062Chondrocyte differentiationIDAbiological_process
GO:0005102Receptor bindingIPImolecular_function
GO:0005109Frizzled bindingIBAmolecular_function
GO:0005125Cytokine activityIDAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIBAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007269Neurotransmitter secretionIEAbiological_process
GO:0007548Sex differentiationTASbiological_process
GO:0008105Asymmetric protein localizationIEAbiological_process
GO:0009953Dorsal/ventral pattern formationIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010469Regulation of receptor activityIC IDAbiological_process
GO:0014719Satellite cell activationIEAbiological_process
GO:0014834Satellite cell maintenance involved in skeletal muscle regenerationIEAbiological_process
GO:0021707Cerebellar granule cell differentiationIEAbiological_process
GO:0021846Cell proliferation in forebrainIDAbiological_process
GO:0022009Central nervous system vasculogenesisIEAbiological_process
GO:0030010Establishment of cell polarityIEAbiological_process
GO:0030182Neuron differentiationIBAbiological_process
GO:0031133Regulation of axon diameterIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0035115Embryonic forelimb morphogenesisIMPbiological_process
GO:0035116Embryonic hindlimb morphogenesisIMPbiological_process
GO:0035567Non-canonical Wnt signaling pathwayIEAbiological_process
GO:0035659Wnt signaling pathway involved in wound healing, spreading of epidermal cellsIDAbiological_process
GO:0042733Embryonic digit morphogenesisIMPbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0045165Cell fate commitmentIBAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046330Positive regulation of JNK cascadeIBAbiological_process
GO:0048018Receptor agonist activityIC IDAmolecular_function
GO:0048103Somatic stem cell divisionIEAbiological_process
GO:0048864Stem cell developmentIDAbiological_process
GO:0050768Negative regulation of neurogenesisIDAbiological_process
GO:0050808Synapse organizationIEAbiological_process
GO:0051965Positive regulation of synapse assemblyIDAbiological_process
GO:0060021Palate developmentIMPbiological_process
GO:0060054Positive regulation of epithelial cell proliferation involved in wound healingIDAbiological_process
GO:0060066Oviduct developmentIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIDAbiological_process
GO:0061038Uterus morphogenesisIEAbiological_process
GO:0070307Lens fiber cell developmentISSbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEPbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:2000273Positive regulation of receptor activityIC IDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.56921050110.88423808750.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0013546393
GSE13712_SHEARUp0.1392032145
GSE13712_STATICDown-0.0094962707
GSE19018Up0.1101540739
GSE19899_A1Down-0.0384281023
GSE19899_A2Up0.2349625229
PubMed_21979375_A1Up0.2416307452
PubMed_21979375_A2Up0.0486019867
GSE35957Up0.0595157665
GSE36640Up0.0253810121
GSE54402Up0.0414842192
GSE9593Up0.0532297136
GSE43922Down-0.0101344836
GSE24585Up0.2685074993
GSE37065Down-0.1667571024
GSE28863_A1Down-0.1399674621
GSE28863_A2Up0.1637918775
GSE28863_A3Up0.1223323273
GSE28863_A4Up0.0449060241
GSE48662Down-0.0503032711

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26473947Wnt7a is a novel inducer of beta-catenin-independent tumor-suppressive cellular senescence in lung cancer
25728679Wnt7a is a novel inducer of beta-catenin-independent tumor-suppressive cellular senescence in lung cancer
25728679Here we identify Wnt7a as a novel upstream inducer of cellular senescence
25728679In two different mouse strains (C57Bl/6J and FVB/NJ), we show that the loss of Wnt7a is a major contributing factor for increased lung tumorigenesis owing to reduced cellular senescence, and not reduced apoptosis, or autophagy
25728679Interestingly, Wnt7a induced an alternate senescence pathway, which was independent of beta-catenin, and distinct from that of classical oncogene-induced senescence mediated by the well-known p16(INK4a) and p19(ARF) pathways
25728679Additionally, we identified Iloprost, a prostacyclin analog, which initiates downstream signaling cascades similar to that of Wnt7a, as a novel inducer of cellular senescence, presenting potential future clinical translational strategies
25728679Thus pro-senescence therapies using either Wnt7a or its mimic, Iloprost, might represent a new class of therapeutic treatments for lung cancer
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