HCSGD entry for WNT1

1. General information

Official gene symbolWNT1
Entrez ID7471
Gene full namewingless-type MMTV integration site family, member 1
Other gene symbolsBMND16 INT1 OI15
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000578Embryonic axis specificationISSbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0005109Frizzled bindingIBA ICmolecular_function
GO:0005125Cytokine activityISSmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIBAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007267Cell-cell signalingISSbiological_process
GO:0007520Myoblast fusionIEAbiological_process
GO:0008284Positive regulation of cell proliferationIDA IMPbiological_process
GO:0009611Response to woundingIEPbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010469Regulation of receptor activityICbiological_process
GO:0010592Positive regulation of lamellipodium assemblyIMPbiological_process
GO:0010812Negative regulation of cell-substrate adhesionIDAbiological_process
GO:0016055Wnt signaling pathwayIDAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021527Spinal cord association neuron differentiationIEAbiological_process
GO:0021536Diencephalon developmentIEAbiological_process
GO:0021551Central nervous system morphogenesisISSbiological_process
GO:0021588Cerebellum formationISSbiological_process
GO:0021797Forebrain anterior/posterior pattern specificationIEAbiological_process
GO:0022004Midbrain-hindbrain boundary maturation during brain developmentIEAbiological_process
GO:0022408Negative regulation of cell-cell adhesionIMPbiological_process
GO:0030182Neuron differentiationIBAbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIMPbiological_process
GO:0030579Ubiquitin-dependent SMAD protein catabolic processIEAbiological_process
GO:0030901Midbrain developmentISSbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0042770Signal transduction in response to DNA damageIDAbiological_process
GO:0043568Positive regulation of insulin-like growth factor receptor signaling pathwayIDAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0044336Canonical Wnt signaling pathway involved in negative regulation of apoptotic processIMPbiological_process
GO:0045165Cell fate commitmentIBAbiological_process
GO:0045599Negative regulation of fat cell differentiationISSbiological_process
GO:0045747Positive regulation of Notch signaling pathwayIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMP ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048018Receptor agonist activityICmolecular_function
GO:0048146Positive regulation of fibroblast proliferationIMPbiological_process
GO:0048664Neuron fate determinationIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityISSbiological_process
GO:0060061Spemann organizer formationISSbiological_process
GO:0060070Canonical Wnt signaling pathwayIMPbiological_process
GO:0060348Bone developmentIMPbiological_process
GO:0061184Positive regulation of dermatome developmentIDAbiological_process
GO:0070365Hepatocyte differentiationIEAbiological_process
GO:0071375Cellular response to peptide hormone stimulusIEAbiological_process
GO:0071425Hematopoietic stem cell proliferationIEAbiological_process
GO:0090344Negative regulation of cell agingIDAbiological_process
GO:2000059Negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processIEAbiological_process
GO:2000273Positive regulation of receptor activityICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.64361570990.81173482390.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0064145412
GSE13712_SHEARUp0.0096350404
GSE13712_STATICUp0.0171926001
GSE19018Up0.1321824092
GSE19899_A1Up0.0597589603
GSE19899_A2Up0.0496190911
PubMed_21979375_A1Up0.0090380397
PubMed_21979375_A2Down-0.2217801473
GSE35957Up0.1183199390
GSE36640Down-0.0166536228
GSE54402Down-0.1007983900
GSE9593Up0.0630925043
GSE43922Up0.0280753415
GSE24585Up0.1509568505
GSE37065Down-0.0578996447
GSE28863_A1Down-0.0840016086
GSE28863_A2Down-0.0515207861
GSE28863_A3Up0.4013460002
GSE28863_A4Up0.1425972379
GSE48662Down-0.0775648896

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-122-5pMIMAT0000421MIRT006421Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22276989
hsa-miR-34a-5pMIMAT0000255MIRT001231Luciferase reporter assayFunctional MTI19336450
hsa-miR-34a-5pMIMAT0000255MIRT001231Flow//Immunoblot//Luciferase reporter assay//Microarray//qRT-PCRFunctional MTI19398721
hsa-let-7e-5pMIMAT0000066MIRT005718Flow//Immunoblot//Luciferase reporter assay//Microarray//qRT-PCRFunctional MTI19398721
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-34a-5pMIMAT0000255NAhsa-miR-34a19398721
hsa-let-7e-5pMIMAT0000066NAhsa-let-7e19398721
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23258168Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically
19733540Here, we explored the consequences of persistent expressing Wnt1 in an epidermal compartment that includes the epithelial stem cells
19733540Although Wnt1 induced the activation of beta-catenin and the mTOR pathway, both hair follicle hyperproliferation and stem cell exhaustion were strictly dependent on mTOR function
17100566The results may have two important implications for oncogene-blocking therapies: (i) downregulation of oncogenes, for instance HER2, MYC, RAS, RAF, BCR-ABL or WNT1, usually leads to a rapid tumor remission
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